Depression and cognitive complaints following mild traumatic brain injury
Abstract
Traumatic brain injury (TBI) is a common occurrence with multiple possible neuropsychiatric sequelae, including problems with cognition, emotion, and behavior. While many individuals experience significant improvement over the first months following mild TBI, a nontrivial minority will develop persistent, functionally impairing post-TBI symptoms. Depression and cognitive impairment are among the most common such symptoms, and they may respond to a combination of rehabilitative and pharmacologic treatments. This article discusses the clinical approach to treating an individual with depression and cognitive complaints following mild TBI. Recommendations regarding the diagnosis, evaluation, and treatment of these problems are offered.
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Current or former service members who have sustained one or more concussions during their service have significantly higher rates of persistent depressive symptoms and suicidality following injury compared to non-injured peers.
“Military service members (SMs) and veterans who have sustained one or more concussions during their service have significantly higher rates of persistent depressive symptoms and suicidality compared to non-injured peers.”
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References 75 · Cited by 315
- Authors
- Silver, J. M., McAllister, T. W., & Arciniegas, D. B.
- Affiliations
- New York University (US)
- Venue
- American Journal of Psychiatry
- Published
- 2009-06
- Volume
- 166
- Issue
- 6
- Pages
- 653-661
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2156217610
- Cited by
- 315
- References
- 75
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 17 · 2023: 8 · 2022: 18 · 2021: 14 · 2020: 10 · 2019: 29 · 2018: 13 · 2017: 25 · 2016: 23 · 2015: 30 · 2014: 20 · 2013: 22 · 2012: 24
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS055020, R01-NS-40472-01, R01NS040472)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD048176, R01HD48638, R01HD048638)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- mild traumatic brain injury, post-traumatic depression, cognitive complaints, cognitive impairment, neuropsychiatric sequelae, rehabilitation, pharmacotherapy
- MeSH terms
- Central Nervous System Stimulants, Antidepressive Agents, Tricyclic, Brain, Brain Injuries, Choline, Cognition Disorders, Depression, Humans, Methylphenidate, Neuropsychological Tests, Severity of Illness Index, Citalopram, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors, Sertraline
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