Special Report: AI-Induced Psychosis: A New Frontier in Mental Health
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Neuroimaging data revealed that AI-assisted brainstorming activated only the right dorsolateral prefrontal cortex (DLPFC), whereas traditional methods activated bilateral DLPFC.
“Neuroimaging data revealed that AI-assisted brainstorming activated only the right dorsolateral prefrontal cortex (DLPFC), whereas traditional methods activated bilateral DLPFC”
From The hidden functions of sycophancy in AI systems: steering, consistency, and cognitive dependency (2026) · cites this paper as [18]
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Shoggoths, Sycophancy, Psychosis, Oh My: Rethinking Large Language Model Use and Safety
Clegg, K. (2025) · Journal of Medical Internet Research · doi:10.2196/87367 · Cited by 17 · see citing works
Ueda, M., Birnbaum, M. L., Liu, Y., Yu, Q., Tian, X., Mirer, A., Ramanathan, S., & Sinyor, M. (2026) · JMIR Mental Health · doi:10.2196/88196 · Cited by 22 · see citing works
Chung, V.-H.-A., Bernier, P., & Hudon, A. (2026) · JMIR Mental Health · doi:10.2196/93040 · Cited by 13 · see citing works
The hidden functions of sycophancy in AI systems: steering, consistency, and cognitive dependency
Jacobowitz, S. (2026) · AI & SOCIETY · doi:10.1007/s00146-026-02993-z · Cited by 4 · see citing works
Seven Desiderata for Ethical Frameworks for AI Mental Health Agents
Smith, W., Earp, B. D., & Buck, B. (2026) · The American Journal of Bioethics · doi:10.1080/15265161.2025.2608637 · Cited by 2 · see citing works
“E.g., they struggle to stratify suicide risk (McBain et al. 2025) and may even contribute to psychotic decompensation, that is, a worsening or breakdown of mental functioning in which psychotic symptoms (re)emerge or intensify (Preda 2025).”
Smith, A. C., Aggarwal, R., Castillo, E. G., Morreale, M. K., Coverdale, J., Seritan, A. L., & Brenner, A. M. (2026) · Academic Psychiatry · doi:10.1007/s40596-026-02326-8 · Cited by 1 · see citing works
“Models are not always transparent on the data sets for training, and cultural gaps and biases have been found [1, 38, 43].”
InfluentialOlisaeloka, L., Nuñez, J.-J., Vigo, D., & Ng, R. (2026) · BJPsych Open · doi:10.1192/bjo.2026.12021 · Cited by 1 · see citing works
Artificial Intelligence in Spiritual Care: Modified Delphi Study
Winiger, F., Smith, C. E., Nourriz, S., Szilagyi, C., & Haußmann, A. D. (2026) · Journal of Medical Internet Research · doi:10.2196/97094 · Cited by 2 · see citing works
Bariach, B., Schoenegger, P., Bhaskar, M., & Suleyman, M. (2026) · AI and Ethics · doi:10.1007/s43681-026-01294-x · Cited by 1 · see citing works
Li, L., Huang, X., Ma, R., Zhang, B. Z., Wu, H., Yang, F., & Chen, C. (2026) · International World Wide Web Conference (WWW) · doi:10.1145/3774904.3793025 · Cited by 1 · see citing works
Is it time for AI to take a leading role in mass trauma mental health response?
Brenner, G. H., Koyfman, S., & Mehendale, R. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117164
AI in Psychotherapy: Opportunities and Risks
Neacşu, V. (2026) · Behavioral Sciences · doi:10.3390/bs16050676 · Cited by 1 · see citing works
“Preda (2025) defines AI psychosis (or AIP) as a complex clinical syndrome in which psychotic symptoms overlap with poor judgment, limited insight, and mood and behavioral changes.”
Pataranutaporn, P., Albrecht, C., Archiwaranguprok, C., Karny, S., & Baez, A. (2026) · Augmented Humans International Conference (AHs) · doi:10.1145/3795011.3795070
“…manifested in documented psychological harms [5]: suicides following extended chatbot relationships [47], homicide planning validated across thousands of messages [70], and psychotic episodes characterized by delusional beliefs concerning AI sentience and altered perception of reality [53, 61, 75].”
InfluentialCooper, J. L., Lundin, S., & Ward-Miller, S. (2026) · Issues in Mental Health Nursing · doi:10.1080/01612840.2026.2644364
“…from adequate reality testing, represent a new challenge, with reported adverse outcomes including addiction, anorexia, depression, psychosis, suicide, homicide, and murder-suicide (Archiwaranguprok et al., 2025; Chen, 2026; Preda, 2025; Singleton et al., 2023; Valentino-DeVries & Hill, 2026).”
How AI Can Enhance Psychological Resilience
Gavankar, M. S., & Ghosh, S. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-7986-9.ch019
Posthuman Sociality of AI-Simulacrum
Ivanchenko, M. A. (2026) · Galactica Media Journal of Media Studies · doi:10.46539/gmd.v8i3.771
RiverBot: Reimagining AI, Technology, and Leadership via Indigenous Co‐Leadership and Relational AI
Caughman, L., Carradını, S., Lauer, C., et al. (2026) · New Directions for Student Leadership · doi:10.1002/yd.70075
“Such approaches can reinforce unhealthy patterns of interaction and, in extreme cases, contribute to harmful outcomes such as AI psychosis (Hudon and Stip 2025 ; Preda 2025 ).”
Leite, F., Gonçalvez, I. X., Moherdaui, L., de Azevedo, T. L., & Silva, T. T. (2026) · Emerging Media · doi:10.1177/27523543261478250
“The study by Nicholls et al. (2026) is instrumental in articulating this analytical discussion.”
InfluentialWiesepape, C. N., Garrelts, J., Stokes, A., Britton, J., Dubas, M., Paul, E., & Gieselman, M. (2026) · Journal of Interdisciplinary Research Applied to Medicine · doi:10.3390/jdream6030014
“These concerns highlight legitimate questions regarding the safety of generative AI for some users, particularly during periods of acute symptom exacerbation or impaired reality testing, risks that have also received attention in recent media coverage [37].”
When Machines Make Humans Feel: Emotion, Intelligence, and the Ethics of AI
Guarini, M. (2026) · Journal of Superintelligence · doi:10.3390/superintelligence1020006
Generative Artificial Intelligence Use and Adolescent Mental Health
Nagata, J. M., Hur, J. O., Diep, T., Alsamman, H., Lee, E. D., Heuer, A., Huynh, H., Nayak, S., McBain, R. K., Cantor, J. H., et al. (2026) · Current Pediatrics Reports · doi:10.1007/s40124-026-00388-8
“Recent high-profile media reports and a shifting pol - icy environment have highlighted concerns about possible links between this rapid adoption of GenAI use and adverse mental health outcomes, including reports of suicidality, psychosis, social withdrawal, and maladaptive emotional reliance [13].”
- Authors
- Preda, A.
- Corresponding author
- Preda, Adrian
- ORCID
- Preda, Adrian
- Venue
- Psychiatric News
- Published
- 2025-10
- Volume
- 60
- Issue
- 10
- ISSN
- 0033-2704 (ISSN-L)
- 1559-1255
- OpenAlex
- W4414600559
- Cited by
- 48
- References
- 0
- Citations by year
- 2026: 47 · 2025: 1
- Type
- other
- Language
- en
- Open access
- closed
- Locations
- Psychiatric News (publishedVersion)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Safety Research › Ethics and Social Impacts of AI
- Keywords
- artificial intelligence, psychosis, mental health
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