Does “Fight or Flight” Need Updating?
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At the same time that cardiac sympathetic tone is increased, vagal cardiac parasympathetic tone is reduced.
“At the same time that cardiac sympathetic tone is increased, vagal cardiac parasympathetic tone is reduced.”
From Fear and the Defense Cascade (2015) · cites this paper as [3]
The reduction in vagal cardiac parasympathetic tone is mediated primarily by efferent vagal fibers that originate from the nucleus ambiguous and fire in synchrony with the respiratory cycle.
“According to current neurophysiological models,3,51 this process is mediated primarily by the efferent vagal fibers that originate from the nucleus ambiguous and that fire in synchrony with the respiratory cycle (respiratory-related cardiac vagal efferents) (see Supplemental Text Box 2, http://links.lww.com/HRP/A9).”
From Fear and the Defense Cascade (2015) · cites this paper as [3]
Because the social-engagement system is interconnected with autonomic regulation of the heart and lungs, engaging with the patient can promote a shift in sympathovagal balance-upregulation of vagal activity and downregulation of sympathetic activity-to a mind-body state of interpersonal connectedness and physiological calm.
“Because the social-engagement system is interconnected with the autonomic regulation of the heart and lungs, the process of engaging with the patient (even in small ways through the use of gaze, tone of voice, or rhythm) can promote a concurrent shift in sympathovagal balance—upregulation of vagal activity and downregulation of sympathetic activity—to a mind-body state of interpersonal connected”
From Fear and the Defense Cascade (2015) · cites this paper as [3]
Drawing on animal research, Porges postulates that hypoxic conditions, such as hyperventilation-induced cerebral hypoxia, increase the probability that sporadically active cardiac vagal neurons in the DMN will be activated, resulting in an episode of collapsed immobility.
“Drawing on animal research, Porges3 postulates that hypoxic conditions—of which hyperventilation-induced cerebral hypoxia is an example—increase the probability that the sporadically active102 cardiac vagal neurons in the DMN will be activated, resulting in an episode of collapsed immobility.”
From Fear and the Defense Cascade (2015) · cites this paper as [3]
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References 7 · Cited by 164
- Authors
- Stefan Bracha, H., Ralston, T. C., Matsukawa, J. M., Williams, A. E., & Bracha, A. S.
- Affiliations
- National Center for PTSD (US)
- University of Hawaiʻi at Mānoa (US)
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 45
- Issue
- 5
- Pages
- 448-449
- ISSN
- 0033-3182 (ISSN-L)
- OpenAlex
- W2166476827
- Cited by
- 164
- References
- 7
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 4 · 2023: 24 · 2022: 10 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 9 · 2014: 13 · 2013: 8 · 2012: 9
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- CogPrints (University of Southampton) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- fight-or-flight response, stress response, autonomic nervous system, psychosomatic medicine
- MeSH terms
- Humans, Terminology as Topic, Parasympathetic Nervous System, Sympathetic Nervous System
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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