The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive- compulsive disorder
Abstract
This article is intended to elucidate some of the neuropathogenetic mechanisms possibly operative in obsessive-compulsive disorder (OCD). Relevant literature is reviewed, with attention to psychologic, and pathologic considerations. Anatomy, neurochemistry, and known functional associations with neuropathological and behavioral abnormalities of implicated brain regions are discussed. The authors propose that dysfunction of neuronal circuits interconnecting the orbitofrontal cortex, basal ganglia/limbic striatum, and thalamus serves a critical role in the pathogenesis of OCD and that obsessive-compulsive symptoms occur when an aberrant positive feedback loop develops in the reciprocally excitatory frontothalamic neuronal interchange, which is inadequately integrated or inhibited by the ventromedial (limbic) portions of the striatum; the ventromedial striatum may serve to modulate activity in the frontothalamic circuit through a negative feedback loop.
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Cites
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
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Lifetime Prevalence of Specific Psychiatric Disorders in Three Sites
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Selemon, L., & Goldman-Rakic, P. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-03-00776.1985 · Cited by 1,073
The mysterious motor function of the basal ganglia: The Robert Wartenberg Lecture
Marsden, C. D. (1982) · Neurology · doi:10.1212/wnl.32.5.514 · Cited by 920
Baxter, L. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800150017003 · Cited by 860
Hippocampal Efferents Reach Widespread Areas of Cerebral Cortex and Amygdala in the Rhesus Monkey
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Stereotyped activities produced by amphetamine in several animal species and man
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Cited by
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Basal ganglia and cerebellar loops: motor and cognitive circuits
Middleton, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00040-5 · Cited by 1,940
Baxter, L. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820090009002 · Cited by 1,293
Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex
Volkow, N. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.318 · Cited by 1,240
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924
Metadata
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 1989-02-01
- Volume
- 1
- Issue
- 1
- Pages
- 27-36
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W1629485274
- Cited by
- 425
- References
- 68
- FWCI
- 17.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive- compulsive disorder. (1989). The Journal of Neuropsychiatry and Clinical Neurosciences. https://doi.org/10.1176/jnp.1.1.27
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
