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Cited by 280

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Patterns of Psychotropic Drug Prescription for U.S. Patients With Diagnoses of Bipolar Disorders

Open access
Baldessarini, Ross J., Leahy, Leslie, Arcona, Stephen, Gause, Douglas, Zhang, Winnie, Hennen, John·2007·Psychiatric Services
DOI 10.1176/ps.2007.58.1.85
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Abstract

OBJECTIVE: Bipolar disorders are prevalent major illnesses with high rates of morbidity, comorbidity, disability, and mortality. A growing number of psychotropic drugs are used to treat bipolar disorder, often off-label and in untested, complex combinations. METHODS: To quantify utilization rates for psychotropic drug classes, this study used the 2002-2003 U.S. national MarketScan research databases to identify 7,760 persons with ICD-9 bipolar disorder subtypes. Survival analysis was used to estimate times until initial monotherapies were augmented, changed, or discontinued. RESULTS: The most commonly prescribed first drug class was antidepressants (50% of patients), followed by mood stabilizers (25%: anticonvulsants, 17%, and lithium, 8%), sedatives (15%), and antipsychotics (11%). At study midpoint only 44% of patients were receiving monotherapy. Those receiving monotherapy were ranked by initial drug prescribed and percentage of patients (bipolar I and bipolar II): antidepressants (55% and 65%), lithium (51% and 41%), antipsychotics (32% and 31%), anticonvulsants (28% and 29%), and sedatives (28%, 25%). Median time to adding another psychotropic was 2.5-times less than median time to changing the initial treatment (16.4 compared with 40.9 weeks), and stopping was rare. Median weeks until therapy was changed in any way for 25% of patients was as follows: lithium, 29 weeks; antidepressants, 13; anticonvulsants, 13; antipsychotics, 13; and sedatives, 9. CONCLUSIONS: Antidepressants were the first-choice agent twice as often as mood stabilizers. Lithium was sustained longer than monotherapy with other mood stabilizers. Time to augmentation was much shorter than time to change or discontinuation.

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Metadata

Authors
Baldessarini, R. J., Leahy, L., Arcona, S., Gause, D., Zhang, W., & Hennen, J.
Venue
Psychiatric Services
Publisher
American Psychiatric Association Publishing
Published
2007-01
Volume
58
Issue
1
Pages
85-91
ISSN
  • 0022-1597 (ISSN-L)
  • 1075-2730
  • 1557-9700
DOI
10.1176/ps.2007.58.1.85
OpenAlex
W2115503446
Cited by
280
References
8
FWCI
11.10
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Patterns of Psychotropic Drug Prescription for U.S. Patients With Diagnoses of Bipolar Disorders. https://app.cochat.ai/papers/10.1176/ps.2007.58.1.85
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Baldessarini, R. J., Leahy, L., Arcona, S., Gause, D., Zhang, W., & Hennen, J. (2007). Patterns of Psychotropic Drug Prescription for U.S. Patients With Diagnoses of Bipolar Disorders. Psychiatric Services. https://doi.org/10.1176/ps.2007.58.1.85

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.