The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Meta-analysis of Major Depressive Disorder Relapse and Recurrence With Second-Generation Antidepressants
Open accessAbstract
OBJECTIVE: This meta-analysis reviewed data on the efficacy and effectiveness of second-generation antidepressants for preventing major depression relapse and recurrence during continuation and maintenance phases of treatment, respectively. METHODS: MEDLINE, EMBASE, and PsycINFO, the Cochrane Library, and International Pharmaceutical Abstracts were searched for the period of January 1980 through April 2007 for reviews, randomized controlled trials, meta-analyses, and observational studies on the topic. Two persons independently reviewed abstracts and full-text articles using a structured data abstraction form to ensure consistency in appraisal and data extraction. RESULTS: Four comparative trials and 23 placebo-controlled trials that addressed relapse or recurrence prevention were included. Results of comparative trials have not demonstrated statistically significant differences between duloxetine and paroxetine, fluoxetine and sertraline, fluvoxamine and sertraline, and trazodone and venlafaxine. Pooled data for the class of second-generation antidepressants compared with placebo suggested a relatively large effect size that persists over time. For preventing both relapse and recurrence, the number of patients needed to treat is five (95% confidence interval of 4 to 6). Differences in the length of open-label treatment before randomization, drug type, and trial duration did not affect pooled estimates of relapse rates. Across all trials, 7% of patients randomly assigned to receive active treatment and 5% of patients randomly assigned to receive a placebo discontinued treatment because of adverse events. CONCLUSIONS: This review demonstrates the overall benefits of continuation- and maintenance-phase treatment of major depression with second-generation antidepressants and emphasizes the need for additional studies of comparative differences among drugs.
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Citations
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643
Selective publication of antidepressant trials and its influence on apparent efficacy
Turner, E. H., Matthews, A. M., Linardatos, E., Tell, R. A., & Rosenthal, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmsa065779 · Cited by 2,435
Publication and related bias in meta-analysis
Sterne, J. A. C., Gavaghan, D., & Egger, M. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00242-0 · Cited by 2,282
Current methods of the U.S. Preventive Services Task Force
Harris, R., Helfand, M., Woolf, S. H., Lohr, K. N., Mulrow, C. D., Teutsch, S. M., & Atkins, D. C. (2001) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(01)00261-6 · Cited by 1,720
Self-citationDistributed Disturbances in Brain Structure and Function in Schizophrenia
Lewis, D. A. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.1 · Cited by 971
Song, F., Altman, D. G., Glenny, A., & Deeks, J. J. (2003) · BMJ · doi:10.1136/bmj.326.7387.472 · Cited by 947
Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
Geddes, J. R., Carney, S. M., Davies, C., Furukawa, T. A., Kupfer, D. J., Frank, E., & Goodwin, G. M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12599-8 · Cited by 945
Research works printed but not linked: 14
- Gaynes is with the Department of Psychiatry, Ms., Thieda is with Cecil G
- Austria Dr., Krebs is with the Department of Medicine
- Dr, Hansen at the School of Pharmacy
- not reported
- Montgomery-Asberg Depression Rating Scale (possible scores range from 0 to 60, with higher scores indicating greater severity of symptoms)
- not applicable
- Clinical Global Impression of Severity (possible scores range from 1 to 7, with lower scores indicating normalcy or mild illness and higher scores indicating more severe illness)
- with higher scores indicating greater severity of symptoms) d SR, sustained release e Active treatment versus placebo f Not included in meta-analysis
- Depression Guideline Panel, 1993, Md, US Department of Health and Human Services, Public Health Service
- Loonen AJ, 1991, Scientific Edition, 13, 167
- Undertaking Systematic Reviews, 2001, CRD's Guidance for Those Carrying Out or Commissioning Reviews. CRD report no 4
- Egger M, 2001, Smith GD
- Gartlehner G, 2006, Md
- Glenny AM, 2005, Indirect comparisons of competing interventions. Health Technology Assessment 9(special issue):1-134
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Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression
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Could Treatment Matching Patients’ Beliefs About Depression Improve Outcomes?
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Lohse, M. J., & Müller-Oerlinghausen, B. (2015) · Springer eBooks · doi:10.1007/978-3-662-47186-9_38 · Cited by 3
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Leucht, S., Heres, S., & Davis, J. M. (2011) · Der Nervenarzt · doi:10.1007/s00115-011-3349-9 · Cited by 3
Cue-Centered Therapy for Youth Experiencing Posttraumatic Symptoms
Carrión, V. G. (2015) · doi:10.1093/med:psych/9780190201326.001.0001 · Cited by 3
Jacobsen, P. L., Zhong, W., Xu, R., & Nomikos, G. G. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.090 · Cited by 3
Evidence-based pharmacotherapy of major depressive disorder
Dupuy, J. M., Ostacher, M. J., Huffman, J. C., Perlis, R. H., & Nierenberg, A. A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511910395.005 · Cited by 3
Yang, C., Han, J., Sun, N., Liu, P., Zhang, K., Zhang, A., & Liu, Z. (2025) · CNS Spectrums · doi:10.1017/s1092852925000252 · Cited by 1
Artificial intelligence and major depression: Toward mechanistic and clinically actionable models
Özsoy, F., Tasci, G., Taşçı, B., Doğan, Ş., & Tuncer, T. (2026) · World Journal of Psychiatry · doi:10.5498/wjp.117452 · Cited by 1
Duloxetine in the acute and continuation treatment of major depressive disorder
Bochsler, L., Olver, J. S., & Norman, T. R. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.133 · Cited by 1
Stratégie thérapeutique des épisodes dépressifs. Prévention du risque de récidive
Nuss, P. (2010) · L Encéphale · doi:10.1016/s0013-7006(10)70048-8 · Cited by 1
Moriarty, A. S., Robertson, L., Mughal, F., Cook, N., Gilbody, S. M., McMillan, D., Chew-Graham, C. A., Ali, S., Hetrick, S. E., Churchill, R. C., et al. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014832 · Cited by 1
Lohse, M. J., & Müller-Oerlinghausen, B. (2012) · Springer eBooks · doi:10.1007/978-3-642-29242-2_39 · Cited by 1
Laux, G. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_67 · Cited by 2
Schneider, C., & Wissink, T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00005-0 · Cited by 2
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Are SSRI Antidepressants Little More than Active Placebo? A Critical Exploration.
Abi‐Jaoude, E. (2011) · Cited by 1
Molecular simulation and drug design.
Lybrand, T. P. (1991) · PubMed · Cited by 1
Cognitive-Behavioural Therapy Combined with Antidepressants for Major Depressive Disorder
Maneeton, N. (2012) · InTech eBooks · doi:10.5772/30340
Leucht, S., Hierl, S., Kissling, W., Dold, M., & Davis, J. M. (2012)
Santone, G., Bellantuono, C., & Psichiatrica, C. (2009)
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Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0006
Diagnostic Criteria and Assessment
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0002
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0003
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0005
Introductory Information for Therapists
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0001
Bronsveld, J. A. (2016) · Utrecht University Repository (Utrecht University)
Behavioural interventions for life style diseases
Isaac, M., & Rief, W. (2017) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000353
Klinische Wirksamkeit der Schematherapie bei Depressionen
Rein, M. L., Höhn, D., & Keck, M. E. (2018) · NeuroTransmitter · doi:10.1007/s15016-018-6218-y
Carneiro, A. M. (2019) · doi:10.11606/t.5.2019.tde-07052019-142600 · Cited by 1
Mood Stabilizers: Classification, Indications and Differential Indications
Menke, A. (2020) · Springer eBooks · doi:10.1007/978-3-319-56015-1_36-1
McLaughlin, P., & Cleare, A. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781911623465.009
Influences On Monoamine Oxidase Activity In The Brain And Translation Into Major Depressive Disorder
Raitsin, S. (2018) · TSpace (University of Toronto)
Personalized treatment strategies for depression
van Bronswijk, S. C. (2020) · Research Publications (Maastricht University) · doi:10.26481/dis.20201211sb
Lohse, M. J., & Müller-Oerlinghausen, B. (2013) · Springer eBooks · doi:10.1007/978-3-642-37124-0_39
Lohse, M. J., & Müller-Oerlinghausen, B. (2017) · Springer eBooks · doi:10.1007/978-3-662-54630-7_41
Joel Paris, M. D. (2010) · Wiley eBooks · doi:10.1002/9780470666630.refs
Laux, G. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_67-1
Current awareness in human psychopharmacology
(2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.973
Laux, G. (2011) · Springer eBooks · doi:10.1007/978-3-642-03637-8_55
Lohse, M. J., & Müller-Oerlinghausen, B. (2014) · Springer eBooks · doi:10.1007/978-3-662-43487-1_39
Yoo, J.-M., Kim, S., Um, Y. H., Kim, T., Seo, H., Hong, S., & Jeong, J. (2021) · Mood and Emotion · doi:10.35986/me.2021.19.2.64
Managing Depression as a Long Term Condition
Rao, S. (2014) · Journal of Neurology and Psychology · doi:10.13188/2332-3469.1000013
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0015
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0014
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0004
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0011
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0012
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0008
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0013
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0009
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.003.0010
Mood Stabilizers: Classification, Indications and Differential Indications
Menke, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_36
Management of Major Depressive Disorder: Basic Principles
Arnone, D., Tirumalaraju, V., & Selvaraj, S. (2024) · Cambridge University Press eBooks · doi:10.1017/9781108973922.019
Chapter 2. Unipolar and Bipolar Depression
Rothschild, A. J. (2011) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378166.lg02
(2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.002.0004
Carrión, V. G. (2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.005.0001
(2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.002.0007
(2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.002.0012
(2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.002.0011
(2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.002.0006
(2015) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190201326.002.0005
Central neuromodulators in gastroenterology and gastropsychology. Focus on irritable bowel syndrome
Gubska, O., & Vanchytskiy, A. O. (2026) · GASTROENTEROLOGY · doi:10.22141/2308-2097.60.1.2026.717
Zhao, B., Fan, Y., Ma, Q., Zhang, J., Jin, X., Peng, Y., Xi, W., Wang, J., Yang, J., Wang, S., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03752-8
(2014) · Europe PMC (PubMed Central) · Cited by 24
Metadata
- Authors
- Hansen, R., Gaynes, B., Thieda, P., Gartlehner, G., Deveaugh-Geiss, A., Krebs, E., & Lohr, K.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- RTI International (US)
- Corresponding author
- Hansen, Richard
- Venue
- Psychiatric Services
- Published
- 2008-10
- Volume
- 59
- Issue
- 10
- Pages
- 1121-1130
- ISSN
- 0022-1597 (ISSN-L)
- 1075-2730
- 1557-9700
- PMC
- PMC2840386
- OpenAlex
- W4236472310
- Cited by
- 172
- References
- 45
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 16 · 2016: 5 · 2015: 32 · 2014: 7 · 2013: 6 · 2012: 13
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatric Services (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- Pfizer
- GlaxoSmithKline
- RTI International
- Shire
- National Institutes of Health
- Agency for Healthcare Research and Quality (290-02-0016)
- University of North Carolina at Chapel Hill
- National Institute of Mental Health
- National Center for Research Resources (K12RR023248)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, depression relapse, depression recurrence, second-generation antidepressants, continuation treatment, maintenance therapy, duloxetine, paroxetine, fluoxetine, sertraline, fluvoxamine, trazodone, venlafaxine, antidepressant efficacy, adverse events
- MeSH terms
- Adult, Aged, Aged, 80 and over, Depressive Disorder, Major, Major Depressive Disorder, Humans, Middle Aged, Recurrence, Randomized Controlled Trials as Topic, Outcome Assessment, Health Care, Antidepressive Agents, Second-Generation
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