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Cited by 9Adrenal Hormones and DisordersSinusitis and nasal conditionsPharmacovigilance and Adverse Drug Reactions

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Off-Label Use of Ciprofloxacin/Dexamethasone Drops in the Pediatric Upper Airway: Case Presentation and Review of Adverse Effects

Ben-Dov, Tom, Yang, Jackie, April, Max M.·2023·Annals of Otology, Rhinology & Laryngology
DOI 10.1177/00034894221104461
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Abstract

Objective: This report describes a new observation of hyperglycemia in a child with Type 1 diabetes after off-label use of otic ciprofloxacin/dexamethasone drops in the nasal passage and reviews previous reports of adverse endocrine effects from intranasal corticosteroids in pediatric patients. Methods: We describe the clinical case and conducted a literature review of MEDLINE (PubMed) and EMBASE. Results: A 9-month-old female with a history of Type 1 diabetes who underwent unilateral choanal atresia repair was started on 1 week of ciprofloxacin 0.3%/dexamethasone 0.1% otic drops twice a day for choanal obstruction with granulation tissue. While the patient’s airway patency improved, average daily blood glucose increases by 40 to 50 points were noted on the patient’s continuous glucose monitor. The hyperglycemia resolved within 2 days after switching to mometasone furoate 0.05% spray. We also review 21 pediatric otolaryngology cases of iatrogenic Cushing’s syndrome associated with on- and off-label use of topical steroid suspensions in the airway. Patients ranged from 3 months to 16 years in age and used doses of 50 μg/day to 2 mg/day. Conclusion: This is the first reported pediatric case of increased blood glucose levels associated with intranasal steroid suspensions, to the best of our knowledge. Counseling families on precise dose administration and potential endocrine disturbances is critical when prescribing these medications for off-label use in infants and small children, particularly among patients with underlying endocrine disorders such as diabetes.

Overview

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Crossref · 10.1177/00034894221104461

Cites

39 of 39 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 1

  1. Hashimoto I, 2002, J Med Investig, 49, 61

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Metadata

Authors
Ben-Dov, T., Yang, J., & April, M. M.
Affiliations
  • Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, New York University School of Medicine, New York, NY, USA
  • New York University (US)
  • NYU Langone Health (US)
Corresponding author
April, Max M.
ORCID
Venue
Annals of Otology, Rhinology & Laryngology
Publisher
SAGE Publications
Published
2022-06-15
Volume
132
Issue
5
Pages
589-595
ISSN
  • 0003-4894 (ISSN-L)
  • 1943-572X
DOI
10.1177/00034894221104461
OpenAlex
W4282914517
Cited by
9
References
39
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1
FWCI
0.25
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Annals of Otology Rhinology & Laryngology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
Keywords
off-label drug use, intranasal corticosteroids, hyperglycemia, type 1 diabetes, Cushing's syndrome, choanal atresia, choanal obstruction, granulation tissue, mometasone furoate, continuous glucose monitoring, topical corticosteroids
MeSH terms
Mometasone Furoate, Administration, Intranasal, Blood Glucose, Child, Ciprofloxacin, Dexamethasone, Diabetes Mellitus, Type 1, Female, Humans, Hyperglycemia, Iatrogenic Disease, Infant, Steroids, Suspensions, Off-Label Use, Drug-Related Side Effects and Adverse Reactions

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