The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Age and sex variation in serum albumin concentration: an observational study.
Abstract
Background: In the UK, a common reference interval for serum albumin is widely used irrespective of age or sex. Implicit in this is that laboratories produce analytically similar results. This paper challenges the validity of this approach. Methods: A three-week collection of results sent to all primary care centres in England has been analysed by age, sex and laboratory. In all, 1,079,193 serum albumin reports were included in this analysis. Results: The mean population serum albumin concentration increases to peak at around age 20 years and then decreases with increasing age. Values in females decrease more rapidly but become close to male values at 60 years. The variation between laboratories was large and potentially clinically significant. Conclusions: Reference intervals for serum albumin should be stratified by age and sex. Until there is greater methodological standardization, laboratories should determine their own reference intervals and not accept a single consensus reference interval.
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In people, albumin levels correlate with disease, nutrition, and socio-economic status rather than chronological age.
“In people, albumin levels correlate with disease, nutrition, and socio-economic status rather than chronological age”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [22]
The Aggregated data section reports that mean serum albumin concentration peaks around age 20 and then decreases with increasing age, contrary to the claim’s dismissal of chronological age. The Introduction says albumin is used to monitor disease and assess nutritional status, but our copy does not establish a correlation with socio-economic status. (LLM, conf=0.88)
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Experimental — accuracy not yet measuredIn people, albumin diminishes only marginally, by 2-4% at 75 years of age from its 26 years of age levels.
“albumin diminishes only marginally, by 2-4% at 75 years of age from its 26 years of age levels [21–24].”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [22]
The Aggregated data section reports that serum albumin decreases with age. Table 1 (shown under Discussion; page not provided) gives medians of 43 to 42 g/L for females aged 26–30 versus 71–75, a decrease of about 2.3%, but 45 to 42 g/L for males, a decrease of about 6.7%. Thus the stated 2–4% range fits the female data, not people generally; the paper also reports age groups rather than values at exactly 26 and 75 years. (LLM, conf=0.90)
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Cites
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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
Willard, F. S., Douros, J. D., Gabe, M. B. N., Showalter, A. D., Wainscott, D. B., Suter, T. M., Capozzi, M. E., van der Velden, W. J. C., Stutsman, C., Cardona, G. R., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.140532 · Cited by 541
“We used 640 μM as the [A]T value, as it is the midpoint of the albumin reference interval (62).”
Terekhova, M., Swain, A., Bohacova, P., Aladyeva, E., Arthur, L., Laha, A., Mogilenko, D. A., Burdess, S., Sukhov, V., Kleverov, D., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.10.013 · Cited by 199
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin
Mehdipour, M., Skinner, C., Wong, N., Lieb, M., Liu, C., Etienne, J., Kato, C., Kiprov, D., Conboy, M. J., & Conboy, I. M. (2020) · Aging · doi:10.18632/aging.103418 · Cited by 115
Grønnestad, R., Johanson, S. M., Müller, M. H. B., Schlenk, D., Tanabe, P., Krøkje, Å., Jaspers, V. L. B., Jenssen, B. M., Ræder, E. M., Lyche, J. L., et al. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115670 · Cited by 65
Biological sex differences in pharmacokinetics and adverse drug reactions
Aljohmani, A., & Yildiz, D. (2026) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-025-04721-8 · Cited by 35
Metadata
- Authors
- Weaving, G., Batstone, G. F., & Jones, R. G.
- Affiliations
- Department of Chemical Pathology and Immunology, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK
- Yorkshire Centre for Health Informatics, Leeds University, Leeds, UK
- Venue
- Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
- Publisher
- SAGE Publications
- Published
- 2015-06-12
- Volume
- 53
- Issue
- 1
- Pages
- 106-111
- ISSN
- 0004-5632
- 1758-1001
- Cited by
- 229
- References
- 1
- Language
- en
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