Increased serum concentrations of N ɛ -carboxymethyllysine are related to the presence and the severity of rheumatoid arthritis
Abstract
Background There are limited data regarding the contribution of advanced glycation end products in the presence of rheumatoid arthritis. We investigated whether serum N ɛ -carboxymethyllysine and pentosidine were related to the presence and the severity of rheumatoid arthritis. Methods Eighty patients with rheumatoid arthritis and 30 control subjects were included in a cross-sectional study. The severity of rheumatoid arthritis was assessed using the disease activity score for 28 joints. Serum N ɛ -carboxymethyllysine and pentosidine were measured by enzyme-linked immunosorbent assay. Results Serum N ɛ -carboxymethyllysine and pentosidine concentrations were significantly higher in patients with rheumatoid arthritis vs. control subjects ( P ɛ -carboxymethyllysine and pentosidine concentrations were significantly higher in rheumatoid arthritis patients with high disease activity vs. rheumatoid arthritis patients with moderate disease activity ( P ɛ -carboxymethyllysine was independently associated with the presence of rheumatoid arthritis (OR = 1.21, 95% CI: 1.05-1.39, P = 0.006). Furthermore, in a multivariate stepwise regression analysis, N ɛ -carboxymethyllysine was independently correlated with disease activity score for 28 joints (standardized β = 0.43, P = 0.001). Conclusion Serum N ɛ -carboxymethyllysine and pentosidine were increased during rheumatoid arthritis, and N ɛ -carboxymethyllysine was independently associated with the presence and the severity of rheumatoid a…
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Serum pentosidine levels were higher in RA patients (n = 80) than in controls (n = 30), measured by ELISA.
“| RA | Serum | Control subjects (n = 30) vs. RA patients (n = 80) | ELISA | Higher CML and pentosidine levels in RA patients | [237,238] |”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [237]
Serum CML levels were higher in RA patients (n = 80) than in controls (n = 30), measured by ELISA.
“| RA | Serum | Control subjects (n = 30) vs. RA patients (n = 80) | ELISA | Higher CML and pentosidine levels in RA patients | [237,238] |”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [237]
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References 38 · Cited by 23
- Authors
- Knani, I., Bouzidi, H., Zrour, S., Bergaoui, N., Hammami, M., & Kerkeni, M.
- Affiliations
- University of Monastir (TN)
- Laboratory of Biochemistry, University Hospital-Tahar Sfar, Mahdia, Tunisia
- Hospital Fatuma Bourguiba Monastir (TN)
- Corresponding author
- Kerkeni, Mohsen
- Venue
- Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
- Publisher
- SAGE Publications
- Published
- 2017-11-03
- Volume
- 55
- Issue
- 4
- Pages
- 430-436
- ISSN
- 0004-5632 (ISSN-L)
- 1758-1001
- OpenAlex
- W2808791865
- Cited by
- 23
- References
- 38
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 4 · 2023: 3 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 2
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Clinical Biochemistry International Journal of Laboratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- rheumatoid arthritis, carboxymethyllysine, pentosidine, advanced glycation end products, serum biomarkers, disease activity, DAS28, disease severity
- MeSH terms
- Adult, Arginine, Arthritis, Rheumatoid, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Lysine, Male, Middle Aged, Severity of Illness Index, Biomarkers, Case-Control Studies
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