Late Effects in Long-Term Survivors After Treatment for Childhood Acute Leukemia
Abstract
Background This is a report of late effects in childhood cancer survivors seen in the follow-up clinic of a single institution. Materials and methods There were 324 acute leukemia survivors in the database of the Long Term Follow Up Clinic of Children's National Medical Center from January 1, 1997, through June 30, 2005. Results Of the 324 acute leukemia survivors, 228 were white, 48 black, 20 Hispanic, and 12 other. Their follow-up time was 0 to 25 years (mean 5.3 years). One or more adverse events occurred in 74.1% of the 324 survivors. Defective physical growth was most commonly reported, followed by disturbed neurocognitive function, emotional difficulties, cardiac abnormalities, hypertension, osteoporosis/osteopenia, fractures, and second neoplasms. More black and Hispanic children had acute myeloid leukemia, relapses, cardiac problems, and hypertension than white and other subjects. Conclusion Childhood cancer survivors require lifelong monitoring, with prompt identification and treatment of adverse late effects.
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Late effects of ALL treatment include cardiomyopathy, avascular necrosis of the joints, secondary cancers, and neurocognitive and behavioral challenges.
“These late effects include cardiomyopathy, avascular necrosis of the joints, secondary cancers, and neurocognitive and behavioral challenges (Goldsby et al., 2010; Haddy, Mosher, & Reaman, 2009; Landier, Armenian, & Bhatia, 2015; Mariotto et al., 2009; Schultz et al., 2007a).”
From Brain structure, working memory and response inhibition in childhood leukemia survivors (2017) · cites this paper as Haddy, Mosher, & Reaman, 2009
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References 53 · Cited by 82
- Authors
- Haddy, T. B., Mosher, R. B., & Reaman, G. H.
- Affiliations
- Children's National (US)
- Sinai Hospital (US)
- Corresponding author
- Haddy, Theresa B.
- ORCID
- Reaman, Gregory H.
- Venue
- Clinical Pediatrics
- Publisher
- SAGE Publications
- Published
- 2009-03-04
- Volume
- 48
- Issue
- 6
- Pages
- 601-608
- ISSN
- 0009-9228 (ISSN-L)
- 1938-2707
- OpenAlex
- W2109820375
- Cited by
- 82
- References
- 53
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 10 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 6
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- childhood acute leukemia, late effects, long-term survivors, childhood cancer survivors, growth deficiency, neurocognitive function, emotional problems, cardiac anomalies, hypertension, osteoporosis, fracture, second neoplasms, racial disparities, acute myeloid leukemia, relapse
- MeSH terms
- Adolescent, Antineoplastic Combined Chemotherapy Protocols, Child, Child Development, Child, Preschool, Cognition Disorders, Continuity of Patient Care, Female, Follow-Up Studies, Health Status, Humans, Infant, Infant, Newborn, Learning Disabilities, Male, Neuromuscular Diseases, Obesity, Retrospective Studies, Stress, Psychological, United States, Bone Marrow Transplantation, Survivors, Radiotherapy, Adjuvant, Adolescent Development, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Secondary Prevention
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