Using High-Dose Omega-3 Fatty Acid Supplements to Lower Triglyceride Levels in 10- to 19-Year-Olds
Open accessAbstract
Background. Omega-3 fatty acids supplements lower triglyceride (TG) levels in adults; little pediatric information is available. We evaluated their effect in hypertriglyceridemic adolescents. Methods. Twenty-five patients aged 10 to 19 years with TG levels 150 to 1000 mg/dL were randomized to 6 months double-blind trial of Lovaza (~3360 mg docosahexaenoic acid + eicosapentaenoic acid per day) versus placebo. Results. Baseline mean TG levels were 227 mg/dL (standard deviation = 49). TG levels declined at 3 months in the Lovaza group by 54 ± 27 mg/dL (mean ± standard error; P = .02) and by 34 ± 26 mg/dL ( P = .16) in the placebo group. The difference in TG lowering between groups was not significant ( P = .52). There were no between-group differences in endothelial function, blood pressure, body mass index, C-reactive protein, or side effects. Conclusions. High-dose omega-3 fatty acid supplements are well tolerated in adolescents. However, declines in TG levels did not differ significantly from Placebo in this small study.
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References 46 · Cited by 58
- Authors
- de Ferranti, S. D., Milliren, C. E., Denhoff, E. R., Steltz, S. K., Selamet Tierney, E. S., Feldman, H. A., & Osganian, S. K.
- Affiliations
- Department of Cardiology, Boston Children’s Hospital, Boston, MA, USA
- Boston Children's Hospital (US)
- Venue
- Clinical Pediatrics
- Publisher
- SAGE Publications
- Published
- 2014-04-04
- Volume
- 53
- Issue
- 5
- Pages
- 428-438
- ISSN
- 0009-9228 (ISSN-L)
- 1938-2707
- PMC
- PMC4353654
- OpenAlex
- W2076126598
- Cited by
- 58
- References
- 46
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 5
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K23HL085308)
- National Center for Research Resources (UL1RR025758)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- omega-3 fatty acids, triglyceride lowering, hypertriglyceridemia, adolescents, docosahexaenoic acid, eicosapentaenoic acid, high-dose supplementation, endothelial function, blood pressure, C-reactive protein, tolerability
- MeSH terms
- Hypoadrenocorticism, Familial, Adolescent, Blood Pressure, C-Reactive Protein, Carbohydrate Metabolism, Inborn Errors, Child, Double-Blind Method, Endothelium, Vascular, Female, Glycerol Kinase, Humans, Male, Triglycerides, Fatty Acids, Omega-3, Body Mass Index, Dietary Supplements, Young Adult
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