The DOI matches its Crossref record.
Rickets Secondary to Phosphate Depletion: A Sequela of Antacid Use in Infancy
Abstract
Two infants presented with growth failure and were found to have generalized osteomalacia (rickets) due to phosphate depletion from prolonged administration of an aluminum-containing antacid given for the symptoms of colic. One of the infants developed bilateral proptosis due to craniosynostosis related to the underlying metabolic bone disease. The chronic use of aluminum-containing antacids in infants has potential risk for the growing skeleton and is not innocuous. Therefore, antacid therapy should be used in low doses and very cautiously, with routine monitoring of serum calcium and phosphorus in children taking medications which reduce gastrointestinal phosphate absorption.
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“There are case reports of osteomalacia and rickets in infants and adults using Al-containing antacids for the treatment of gastrointestinal illnesses (Chines and Pacifici, 1990; Pivnick et al., 1995; Woodson, 1998).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Pivnick et al., 1995
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Research works printed but not linked: 14
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Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“There are case reports of osteomalacia and rickets in infants and adults using Al-containing antacids for the treatment of gastrointestinal illnesses (Chines and Pacifici, 1990; Pivnick et al., 1995; Woodson, 1998).”
BackgroundAluminum toxicokinetics regarding infant diet and vaccinations.
Keith, L. S., Jones, D. E., & Chou, C.-H. S. J. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00165-2 · Cited by 83
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Metadata
- Authors
- Pivnick, E. K., Kerr, N. C., Kaufman, R. A., Jones, D. P., & Chesney, R. W.
- Affiliations
- University of Tennessee Health Science Center (US)
- University of Massachusetts Chan Medical School (US)
- Le Bonheur Children's Hospital (US)
- University of Tennessee at Knoxville (US)
- Venue
- Clinical Pediatrics
- Publisher
- SAGE Publications
- Published
- 1995-02
- Volume
- 34
- Issue
- 2
- Pages
- 73-78
- ISSN
- 0009-9228 (ISSN-L)
- 1938-2707
- OpenAlex
- W2105637516
- Cited by
- 65
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Nephrology › Renal function and acid-base balance
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- rickets, phosphate limitation, osteomalacia, infants, colic, growth failure, craniosynostosis, proptosis, metabolic bone disease
- MeSH terms
- Aluminum Hydroxide, Antacids, Colic, Drug Combinations, Female, Humans, Infant, Intestinal Absorption, Magnesium Hydroxide, Osteomalacia, Phosphates, Radiography, Rickets, Simethicone
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