The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Metabolomics of Supragingival Plaque and Oral Bacteria
Abstract
Dental caries is initiated by demineralization of the tooth surface through acid production by sugar metabolism of supragingival plaque microflora. To elucidate the sugar metabolic system, we used CE-MS to perform metabolomics of the central carbon metabolism, the EMP pathway, the pentose-phosphate pathway, and the TCA cycle in supra- gingival plaque and representative oral bacteria, Streptococcus and Actinomyces. Supragingival plaque contained all the targeted metabolites in the central carbon metabolism, except erythrose 4-phosphate in the pentose-phosphate pathway. After glucose rinse, glucose 6-phosphate, fructose 6-phosphate, fructose 1,6-bisphosphate, dihydroxyacetone phosphate, and pyruvate in the EMP pathway and 6-phosphogluconate, ribulose 5-phosphate, and sedoheptulose 7-phosphate in the pentose-phosphate pathway, and acetyl CoA were increased. Meanwhile, 3-phosphoglycerate and phosphoenolpyruvate in the EMP pathway and succinate, fumarate, and malate in the TCA cycle were decreased. These pathways and changes in metabolites observed in supragingival plaque were similar to the integration of metabolite profiles in Streptococcus and Actinomyces.
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“During the development of periodontal disease, the stresses of a protein-rich, neutral-alkaline environment promote the growth of periodontal pathogens [90].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [90]
In the citing paper
“During the development of periodontal disease, protein‐rich and neutral‐alkaline environmental pressures promote the outgrowth of periodontal pathogens.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [293]
In the citing paper
“Inflammatory processes promote the outgrowth of inflammophilic bacteria via the production of proteinaceous substrates resulting from tissue destruction.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [293]
Citations
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Additional file 4 of Salivary microbiome and metabolome analysis of severe early childhood caries
Li, K., Wang, J., Du, N., Sun, Y., Sun, Q., Yin, W., Li, H., Meng, L., & Liu, X. (2023) · Figshare · doi:10.6084/m9.figshare.22602056
Diverse roles of salivary microbiota in the onset and severity of periodontal disease
Mamillapalli, A., Kumar, S. P., Rashid, M. H., & Didugu, B. G. L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27622-4.00020-1
Septic arthritis drives alveolar bone loss in mice through microbiota-dependent functional shifts
Boff, D., Bambirra, F. H. S., Queiroz‐Junior, C. M., Anestino, T. A., de Oliveira, V. L. S., Ferreira, L. M. A., Lobo, I., Rios, D. L., Teixeira, M. M., Silva, T. A., et al. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108270
Metagenomic analysis of tongue samples from healthy subjects identifies distinct microbiome orotypes
Al-Maweri, S., Ba-Hattab, R., Alomairi, A., Syed, A., Azouni, K. G., Batta, N., Almeer, F., Assad, R., Al-Mansoori, A., Eltai, N. O., et al. (2026) · Journal of Oral Microbiology · doi:10.1080/20002297.2026.2687934
Beyond Acidification: Microbial Lactate in the Oral Microbiome–Host Axis
Takahashi, N. (2026) · Journal of Dental Research · doi:10.1177/00220345261462879
Self-citationFunctional effects of microbial metabolites in dental caries
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Mass Spectrometry-Based Oral Meta-Omics Analysis—What We Know and What We Don’t
Chirițoiu, G. N., Chiritoiu‐Butnaru, M., Porosencova, T., Porosencov, E., Uncuța, D., Istrati, D., Isvoranu, G., Petrescu, A., & Munteanu, C. V. A. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-29437-1_25
Metadata
- Authors
- Takahashi, N., Washio, J., & Mayanagi, G.
- Affiliations
- Tohoku University (JP)
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-10-05
- Volume
- 89
- Issue
- 12
- Pages
- 1383-1388
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2039105696
- Cited by
- 107
- References
- 33
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 12 · 2021: 8 · 2020: 9 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 12 · 2014: 6 · 2013: 5 · 2012: 9
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22792104, 22390399)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- supragingival plaque, oral bacteria, Streptococcus, Actinomyces, sugar metabolism, dental caries, central carbon metabolism, glycolysis, pentose phosphate pathway, TCA cycle, metabolite profiling, acid production
- MeSH terms
- Acetyl Coenzyme A, Actinomyces, Adult, Bacteriological Techniques, Carbon, Citric Acid Cycle, Dental Plaque, Dihydroxyacetone Phosphate, Female, Fructosediphosphates, Fructosephosphates, Fumarates, Gluconates, Glucose, Glyceric Acids, Glycolysis, Humans, Malates, Male, Pentose Phosphate Pathway, Phosphoenolpyruvate, Ribulosephosphates, Streptococcus, Streptococcus mutans, Sugar Phosphates, Pyruvic Acid, Glucose-6-Phosphate, Succinic Acid, Metabolomics
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