Emerging Role of Extracellular Vesicles in Bone Remodeling
Abstract
Extracellular vesicles (EVs), as nanometer-scale particles, include exosomes, microvesicles, and apoptotic bodies. EVs are released by most cell types, such as bone marrow stem cells, osteoblasts, osteoclasts, and immune cells. In bone-remodeling microenvironments, EVs deliver specific proteins (e.g., tenascin C and Sema4D), microRNAs (e.g., miR-214-3p, miR-183-5p, and miR-196a), and other growth factors (e.g., bone morphogenetic protein 1 to 7 and transforming growth factor β1) to osteoblasts and regulate bone formation. In addition, EVs can deliver cytokines, such as RANK (receptor activator of nuclear factor κB) and RANKL (RANK ligand), and microRNAs, such as miR-218 and miR-148a, to modulate osteoclast differentiation during bone resorption. EVs also transfer bioactive molecules and have targeted therapies in bone-related diseases. Moreover, bioactive molecules in EVs are biomarkers in bone-related diseases. We highlight the emerging role of EVs in bone remodeling during physiologic and pathologic conditions and summarize the role of EVs in tooth development and regeneration. At the end of this review, we discuss the challenges of EV application in the treatment of bone diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Coupling of osteoclasts to osteoblasts and related functions involve production of specific extracellular vesicles released by bone cells.
“The coupling of osteoclasts to osteoblasts and related functions involve not only the secretion of factors in the BRC but also the production of specific EVs, released by bone cells. EVs have emerged as important intercellular regulators since they function as messengers from osteoclasts to osteoblasts, and vice versa.236”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [236]
The citation lists haven’t been fetched yet
References 59 · Cited by 142
- Authors
- Liu, M., Sun, Y., & Zhang, Q.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Zhang, Q.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2018-03-22
- Volume
- 97
- Issue
- 8
- Pages
- 859-868
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2792159572
- Cited by
- 142
- References
- 59
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 19 · 2023: 22 · 2022: 27 · 2021: 19 · 2020: 17 · 2019: 11 · 2018: 7
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81371141, 81570966)
- Specialized Research Fund for the Doctoral Program of Higher Education (20130072110020)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- extracellular vesicles, bone remodeling, exosomes, microvesicles, apoptotic bodies, osteoblasts, osteoclastogenesis, bone resorption, bone formation, microRNA, RANK/RANKL signaling, bone morphogenetic proteins, TGF-beta, tooth development, tooth regeneration, bone-related diseases, biomarkers, targeted therapy
- MeSH terms
- Extracellular Vesicles, Animals, Cell Communication, Cell Differentiation, Humans, Biomarkers, Bone Remodeling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
