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Clinical and Microbiological Aspects of Chemotherapeutic Agents Used According to the Specific Plaque Hypothesis
Open accessAbstract
Certain forms of dental decay and periodontal disease appear to be due to specific bacterial infections following overgrowth of certain indigenous plaque bacteria, i.e., the specific plaque hypothesis. If so, then antimicrobial treatment based on a diagnosis of elevated levels or proportions of these organisms should be considered. Such treatment cannot be administered according to concepts of the non-specific plaque hypothesis. A treatment philosophy is presented which is based upon considerations long established in medical infections following overgrowth of certain indigenous plaque bacteria, i.e., the specific plaque hypo-microbial to the site of the infection for periods long enough to suppress or destroy the pathogenic agent. Examples of this treatment philosophy are given.
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Cited by
The oral microbiome – an update for oral healthcare professionals
Kilian, M., Chapple, I. L. C., Hannig, M., Marsh, P. D., Meuric, V., Pedersen, A. M. L., Tonetti, M. S., Wade, W. G., & Zaura, E. (2016) · British Dental Journal · doi:10.1038/sj.bdj.2016.865 · Cited by 1,269
Hajishengallis, G., & Lamont, R. J. (2012) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2012.00663.x · Cited by 1,267
Molecular aspects of the pathogenesis of periodontitis
Meyle, J., & Chapple, I. (2015) · Periodontology 2000 · doi:10.1111/prd.12104 · Cited by 705
Chlorhexidine mouthrinse as an adjunctive treatment for gingival health
James, P., Worthington, H. V., Parnell, C., Harding, M., Lamont, T., Cheung, A., Whelton, H., & Riley, P. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008676.pub2 · Cited by 571
Minimal intervention dentistry for managing dental caries – a review
Frencken, J. E., Peters, M. C., Manton, D. J., Leal, S. C., Gordan, V. V., & Eden, E. (2012) · International Dental Journal · doi:10.1111/idj.12007 · Cited by 531
Metadata
- Authors
- Loesche, W. J.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 1979-12
- Volume
- 58
- Issue
- 12
- Pages
- 2404-2412
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W1991748908
- Cited by
- 255
- References
- 0
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Loesche, W. J. (1979). Clinical and Microbiological Aspects of Chemotherapeutic Agents Used According to the Specific Plaque Hypothesis. Journal of Dental Research. https://doi.org/10.1177/00220345790580120905
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
