The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cost of non-antimicrobials for prophylaxis in the management of recurrent UTIs
Abstract
ObjectiveThe aim of this paper was to look at the cost of the different non-antimicrobials available for the management of recurrent UTIs, and to compare these to the antimicrobials currently recommended for prophylaxis in the United Kingdom.MethodsFive non-antimicrobials (D-mannose, Probiotics/lactobacillus, Methenamine Hippurate, Oestrogens and Cranberry) and four antimicrobials (prophylactic dose Trimethoprim, Nitrofurantoin, Amoxicillin and Cefalexin) were included. The cost for 6 months of prophylactic treatment was calculated for each, with the median and range included for the non-prescription products.ResultsFor a 6-month duration, the median cost of Vaginal oestrogen, Cranberry, Methenamine Hippurate, Probiotics and D-mannose was £22.04, £55.95, £100.44, £139.5 and £158.40 respectively. Vaginal oestrogens were the cheapest non-antimicrobial management option with D-mannose being the most expensive. Trimethoprim was the cheapest of the antimicrobials for 6 months of prophylaxis (£5.08), followed by Cefalexin (£7.97), Amoxicillin (£10.71) and Nitrofurantoin (£16.32).ConclusionThe cost of antimicrobial management options for the prophylaxis of UTIs was found to be generally cheaper across the board, in comparison to non-antimicrobial products. However, the continuing public health crisis with regards to overprescribing of antimicrobials, growing resistance and the need for antimicrobial stewardship makes non-antimicrobials an ever-important consideration.
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“a significant economic and antimicrobial stewardship burden, the development of non-antimicrobial preventive strategies remains of great public health relevance [71, 72].”
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“a significant economic and antimicrobial stewardship burden, the development of non-antimicrobial preventive strategies remains of great public health relevance [71, 72].”
Citations
Cites
Bell, B. G., Schellevis, F., Stobberingh, E., Goossens, H., & Pringle, M. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-13 · Cited by 1,262
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Metadata
- Authors
- Joshi, A., Tzelves, L., Juliebø-Jones, P., Kamal, W., Shrestha, A., & Somani, B.
- Affiliations
- University of Southampton (GB)
- National and Kapodistrian University of Athens (GR)
- Department of Urology, Haukeland University Hospital, Bergen, Norway
- King Fahad Hospital Jeddah (SA)
- Bir Hospital (NP)
- University Hospital Southampton NHS Foundation Trust (GB)
- Corresponding author
- Somani, Bhaskar
- Venue
- Scottish Medical Journal
- Publisher
- SAGE Publications
- Published
- 2025-07-03
- Volume
- 70
- Issue
- 3
- Pages
- 46-53
- ISSN
- 0036-9330 (ISSN-L)
- 2045-6441
- OpenAlex
- W4411972529
- Cited by
- 3
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scottish Medical Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Urinary Tract Infections Management
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Keywords
- recurrent urinary tract infection, cost analysis, D-mannose, probiotics, Lactobacillus, methenamine hippurate, cranberry, antibiotic prophylaxis, trimethoprim, nitrofurantoin, antimicrobial stewardship, antimicrobial resistance
- MeSH terms
- Amoxicillin, Anti-Bacterial Agents, Cephalexin, Female, United Kingdom, Hippurates, Humans, Methenamine, Nitrofurantoin, Recurrence, Trimethoprim, Urinary Tract Infections, Antibiotic Prophylaxis, Probiotics, Vaccinium macrocarpon, Secondary Prevention
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