Dumping Syndrome: Pathophysiology and Treatment
Abstract
Anatomic and physiologic changes introduced by gastric surgery result in clinically significant dumping syndrome in approximately 10% of patients. Dumping is the effect of alteration in the motor functions of the stomach, including disturbances in the gastric reservoir and transporting function. Gastrointestinal hormones play an important role in dumping by mediating responses to surgical resection. Treatment options of dumping syndrome include diet, medications, and surgical revision. Poor nutrition status can be anticipated in patients who fail conservative therapy. Management of refractory dumping syndrome can be a challenge. This review highlights current knowledge about the mechanisms of dumping syndrome and available therapy.
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Patients with severe dumping syndrome may experience weight loss of up to 30% of their preoperative weight.
“Patients with severe dumping syndrome may experience weight loss of up to 30% of their preoperative weight (16).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [16]
Dietary modification is the initial approach used to manage dumping syndrome and is usually beneficial for a majority of patients.
“Dietary modification is the initial approach used to manage dumping syndrome and is usually beneficial for a majority of patients (3,10,16,43-47).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [16]
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References 109 · Cited by 210
- Authors
- Ukleja, A.
- Affiliations
- Cleveland Clinic Florida (US)
- Corresponding author
- Ukleja, Andrew
- ORCID
- Ukleja, Andrew
- Venue
- Nutrition in Clinical Practice
- Publisher
- Wiley
- Published
- 2005-10
- Volume
- 20
- Issue
- 5
- Pages
- 517-525
- ISSN
- 0884-5336 (ISSN-L)
- 1941-2452
- OpenAlex
- W2005279327
- Cited by
- 210
- References
- 109
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 6 · 2023: 12 · 2022: 12 · 2021: 7 · 2020: 14 · 2019: 13 · 2018: 6 · 2017: 9 · 2016: 18 · 2015: 19 · 2014: 11 · 2013: 9 · 2012: 13
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition in Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- dumping syndrome, gastric surgery, gastric emptying, gastric motility, gastrointestinal hormones, postgastrectomy complications, dietary management, pharmacotherapy, surgical revision, nutritional status
- MeSH terms
- Combined Modality Therapy, Dumping Syndrome, Gastrointestinal Agents, Humans, Nutritional Status, Reoperation, Nutrition Therapy
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