The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Fenofibrate-Induced Muscular Toxicity Is Associated with a Metabolic Shift Limited to Type-1 Muscles in Rats
Abstract
Morphological changes and mRNA expression levels in type-1 predominant soleus and type-2 predominant tensor fasciae latae muscles of rats treated with fenofibrate were investigated. After fenofibrate by oral gavage at 300 mg/kg/day for 28 days, degeneration/necrosis and regeneration of muscle fibers, cellular infiltration, and fibrosis were seen in soleus muscle. Additionally, expression of PDK4, CPT1-M, CPT2, and FACO mRNAs was increased. In contrast, no morphological changes or mRNA induction were apparent in tensor fasciae latae muscle. These data suggest that sensitivity to fenofibrate-induced muscle toxicity differs among muscles, with only type-1 fibers being susceptible. The up-regulation of PDK4, CPTs and FACO mRNA expression in soleus muscle indicates that the energy source is switched from glucose to fatty acids, and this might be related to the observed fenofibrate-induced muscular toxicity.
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“Type 1 fibers are more susceptible to fibrate-induced muscle toxicity”
From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Okada et al. 2009
In the citing paper
“the soleus muscle was selected for this study as it is mainly formed of type 1 fibers (Okada et al. 2009)”
From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Okada et al. 2009
Citations
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Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?
El-Bassouny, D. R., Mansour, A. A., Ellakkany, A. S., Ayuob, N. N., & AbdElfattah, A. A. (2023) · Histochemistry and Cell Biology · doi:10.1007/s00418-023-02205-5
“Type 1 fibers are more susceptible to fibrate-induced muscle toxicity, so the soleus muscle was selected for this study as it is mainly formed of type 1 fibers (Okada et al. 2009).”
Background
Metadata
- Authors
- Okada, M., Sano, F., Ikeda, I., Sugimoto, J., Takagi, S., Sakai, H., & Yanai, T.
- Affiliations
- Tanabe Pharma Corporation (Japan) (JP)
- Gifu University (JP)
- Corresponding author
- Okada, Miyoko
- ORCID
- Yanai, Tokuma
- Venue
- Toxicologic Pathology
- Publisher
- SAGE Publications
- Published
- 2009-04-24
- Volume
- 37
- Issue
- 4
- Pages
- 517-520
- ISSN
- 0192-6233 (ISSN-L)
- 1533-1601
- OpenAlex
- W2140374086
- Cited by
- 17
- References
- 25
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicologic Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- fenofibrate, type I muscle fibers, soleus muscle, muscle fibrosis, PDK4, carnitine palmitoyltransferase, fatty acid oxidation
- MeSH terms
- Animals, Hypolipidemic Agents, Data Interpretation, Statistical, Fibrosis, Glucose, Male, Necrosis, Fenofibrate, RNA, Messenger, Gene Expression, Muscle, Skeletal, Muscle Fibers, Slow-Twitch, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Toxicity Tests, Chronic, Lipid Metabolism, Rats
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