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Parenteral Aluminum Compounds Produce a Local Toxic Myopathy in Rats: Importance of the Anion
Open accessAbstract
Aluminum lactate, injected in rats, produced skeletal muscle necrosis of diaphragm and abdominal wall subjacent to peritoneal surfaces. Deeper muscle cells (distal from inoculum) were less severely affected. Ultrastructural studies of diaphragm revealed inoculum coating collagen fibrils, aggregating next to muscle basal lamina and localized within phagocytes. Aluminum lactate penetrated lymphatic vessels and caused reactive changes on the pleural as well as peritoneal surfaces of diaphragm. In contrast, injection of aluminum citrate did not produce myopathy. Also, mixtures of aluminum lactate with aluminum citrate, sodium citrate, or another chelating agent failed to produce myopathy. Therefore, the regional myopathy produced by the lactate salt provides a model for in vivo cytotoxicity of aluminum in which anionic binding is a critical determinant.
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Skeletal muscle necrosis occurred in the diaphragm and abdominal muscles of rats adjacent to the peritoneum after intraperitoneal injection of Al lactate.
“Skeletal muscle necrosis occurred in the diaphragm and abdominal muscles of rats adjacent to the peritoneum after intraperitoneal injection of Al lactate (Levine et al., 1992).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Levine et al., 1992
The Abstract reports skeletal muscle necrosis in the rat diaphragm and abdominal wall subjacent to peritoneal surfaces after aluminum lactate injection. It does not specify that the injection was intraperitoneal, so the stated route is not verified by our copy. (LLM, conf=0.85)
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Research works printed but not linked: 34
- 10.1016/0028-3908(85)90025-5 · DOI
- 10.1016/S0149-7634(89)80051-X · DOI
- 10.1016/S0140-6736(72)90357-1 · DOI
- 10.1016/0041-008X(90)90094-B · DOI
- 10.1289/ehp.9089217 · DOI
- 10.1007/BF02795622 · DOI
- Corain B., 1988, Aging, 9, 413
- 10.1111/j.1600-0773.1989.tb00599.x · DOI
- Crapper McLachlan DR (1989). Aluminum neurotoxicity: Criteria for assigning a role in Alzheimer's disease. In: Environmental Chemistry and Toxicology of Aluminum, TE Lewis (ed). Lewis Publishers, Chelsea, Michigan, pp. 299-315.
- 10.1007/BF02990262 · DOI
- 10.1016/0304-3940(90)90815-Q · DOI
- 10.1016/0041-008X(84)90203-5 · DOI
- 10.1080/15287399009531382 · DOI
- 10.1111/j.1471-4159.1990.tb02352.x · DOI
- Hem SL, 1984, J. Parent. Sci. Technol, 38, 2
- 10.2136/sssaj1986.03615995005000010006x · DOI
- 10.1038/ki.1990.97 · DOI
- Kilarski W., 1990, J. Anat, 168, 13
- Leblondel G., 1980, Res. Commun. Chem. Pathol. Pharmacol, 27, 579
- 10.1016/0014-4800(85)90062-0 · DOI
- Martin RB (1988). Bioinorganic chemistry of aluminum. In: Metal Ions in Biological Systems, Vol. 24. Aluminum and Its Role in Biology , H Sigel and A Sigel (eds). Marcel Dekker, New York, pp. 1-56.
- Nelson WO, Lutz TG, and Orvig C. (1989). The chemistry of neurologically active, neutral, and water soluble aluminum complexes. In: Environmental Chemistry and Toxicology of Aluminum, TE Lewis (ed). Lewis Publishers, Chelsea, Michigan, pp. 271-287.
- 10.1007/BF00688235 · DOI
- Pierides AM, 1978, Int. J. Artif. Organs, 1, 206
- 10.1136/bmj.2.6088.657 · DOI
- 10.1073/pnas.87.22.9024 · DOI
- 10.1002/jps.2600731105 · DOI
- 10.1007/BF01513437 · DOI
- 10.1007/BF00996974 · DOI
- Trapp GA, 1986, Kidney Int, 29, S12
- 10.3109/01480548908999158 · DOI
- 10.1016/S0041-008X(88)80005-X · DOI
- 10.1016/0378-4274(87)90231-1 · DOI
- Zatta P., Perazzolo M., Bombi GG, Corain B., and Nicolini M. (1989). The role of speciation in the effects of aluminum (III) on the stability of cell membranes and on the activity of selected enzymes . In: Alzheimer's Disease and Related Disorders, W Windblad and H Wisniewski (eds). Alan R. Liss, New York , pp. 1087-1091.
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Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“Skeletal muscle necrosis occurred in the diaphragm and abdominal muscles of rats adjacent to the peritoneum after intraperitoneal injection of Al lactate (Levine et al., 1992).”
Background
Metadata
- Authors
- Levine, S., Saltzman, A., & Drakontides, A. B.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- New York Medical College (US)
- Venue
- Toxicologic Pathology
- Publisher
- SAGE Publications
- Published
- 1992-05
- Volume
- 20
- Issue
- 3-1
- Pages
- 405-415
- ISSN
- 0192-6233 (ISSN-L)
- 1533-1601
- OpenAlex
- W2132860959
- Cited by
- 9
- References
- 0
- Citations by year
- 2025: 1 · 2020: 1 · 2019: 1 · 2017: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Toxicologic Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- aluminum toxicity, aluminum lactate, aluminum citrate, skeletal muscle necrosis, diaphragm, aluminum chelation, lymphatic spread, phagocytes, collagen fibrils
- MeSH terms
- Aluminum, Animals, Anions, Antacids, Citrates, Diaphragm, Female, Infusions, Parenteral, Lactates, Male, Muscles, Muscular Diseases, Necrosis, Phagocytosis, Rats, Inbred Strains, Citric Acid, Lactic Acid, Rats
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