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Cited by 60Mercury impact and mitigation studiesHeavy Metal Exposure and ToxicityMedical Case Reports and Studies

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Differential diagnosis between organic and inorganic mercury poisoning in human cases—the pathologic point of view

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Eto, Komyo, Takizawa, Yukio, Akagi, Hirokatsu, Haraguchi, Koichi, Asano, Shigeyuki, Takahata, Naohiko, Tokunaga, Hidehiro·1999·Toxicologic Pathology
DOI 10.1177/019262339902700608
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Abstract

Differences in pathology were found between acute and chronic exposure to methylmercury, mercury vapor, and inorganic mercury. Characteristic pathologic changes produced by organic mercury in the brain have previously been described in patients with Minamata disease. The brains of patients who presented with acute onset of symptoms and died within 2-mo showed loss of neurons with reactive proliferation of glial cells, microcavitation, vascular congestion, petechial hemorrhage, and edema in the cerebral cortices, predominantly in the calcarine, pre- and postcentral, and transverse temporal cortices and in the cerebellar cortex. The neuropathologic changes in the patients with acute onset of symptoms who survived for a long period (>10 yr) were also included neuronal loss with reactive proliferation of glial cells in similar anatomic locations. The neuropathologic changes in patients with inorganic mercury poisoning are quite different. Autopsies performed on 3 individuals with fatal cases of acute inorganic mercury poisoning who were exposed to mercury vapor for about 2 wk revealed diffuse organized pneumonia, renal cortical necrosis, disseminated intravascular coagulopathy, and infarctions in the brain and kidneys. In 2 other patients who worked in mercury mines for about 10 yr and who suffered from chronic inorganic poisoning, no specific lesions were demonstrated in the brain. However, the assay and the histochemistry of mercury revealed that inorganic mercury was present in the brain in all 3 groups irrespective of the brain lesions and the duration of clinical signs.

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Research works printed but not linked: 34

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Metadata

Authors
Eto, K., Takizawa, Y., Akagi, H., Haraguchi, K., Asano, S., Takahata, N., & Tokunaga, H.
Affiliations
  • National Institute for Minamata Disease (JP)
  • Iwaki Kyoritsu General Hospital (JP)
  • Sapporo Medical University (JP)
  • Kumamoto University Hospital (JP)
Corresponding author
Eto, Komyo
ORCID
Haraguchi, Koichi
Venue
Toxicologic Pathology
Publisher
SAGE Publications
Published
1999-11
Volume
27
Issue
6
Pages
664-671
ISSN
  • 0192-6233 (ISSN-L)
  • 1533-1601
DOI
10.1177/019262339902700608
OpenAlex
W2048198488
Cited by
60
References
26
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 1 · 2013: 6 · 2012: 2
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Toxicologic Pathology (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Washington
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Mercury impact and mitigation studies
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Medicine › Internal Medicine › Medical Case Reports and Studies
Keywords
organic mercury poisoning, methylmercury, mercury vapor, Minamata disease, neuropathology, neuronal loss, glial cell proliferation, microcavitation, cerebral cortex lesions, cerebellar cortex, chronic mercury exposure, mercury mines, renal cortical necrosis, disseminated intravascular coagulation, cerebral infarction
MeSH terms
Adult, Aged, Brain, Diagnosis, Differential, Female, Gliosis, Histocytochemistry, Humans, Male, Mercury, Methylmercury Compounds, Middle Aged, Neurons, Reference Values, Spinal Cord, Tissue Distribution, Peripheral Nervous System, Mercury Poisoning, Nervous System

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