The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Effect of 12 months of creatine supplementation and whole-body resistance training on measures of bone, muscle and strength in older males
Abstract
Background: The combination of creatine supplementation and resistance training (10–12 weeks) has been shown to increase bone mineral content and reduce a urinary indicator of bone resorption in older males compared with placebo. However, the longer-term effects (12 months) of creatine and resistance training on bone mineral density and bone geometric properties in older males is unknown. Aim: To assess the effects of 12 months of creatine supplementation and supervised, whole-body resistance training on bone mineral density, bone geometric properties, muscle accretion, and strength in older males. Methods: Participants were randomized to supplement with creatine ( n = 18, 49–69 years, 0.1 g·kg -1 ·d -1 ) or placebo ( n = 20, 49–67 years, 0.1 g·kg -1 ·d -1 ) during 12 months of supervised, whole-body resistance training. Results: After 12 months of training, both groups experienced similar changes in bone mineral density and geometry, bone speed of sound, lean tissue and fat mass, muscle thickness, and muscle strength. There was a trend ( p = 0.061) for creatine to increase the section modulus of the narrow part of the femoral neck, an indicator of bone bending strength, compared with placebo. Adverse events did not differ between creatine and placebo. Conclusions: Twelve months of creatine supplementation and supervised, whole-body resistance training had no greater effect on measures of bone, muscle, or strength in older males compared with placebo.
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“There is also supporting evidence that CrM can increase regional (limb) muscle size and density.”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [123]
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“the change with CrM supplementation over placebo (1.4 mg/cm3) [123] is greater than the difference between older adults classified as fallers versus non-fallers (1.3 mg/cm3) [105].”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [123]
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“CrM also improves lower-leg muscle quality (assessed as muscle density) during one year of supplementation in men and women (age ~58 years of age) compared to placebo during 3 days per week resistance training [123].”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [123]
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Cites
CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials
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Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation
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“Email: darren.candow@uregina.ca creatine ingestion (Harris et al., 1992).”
BackgroundEffects of Resistance Exercise on Bone Health
Hong, A. R., & Kim, S. W. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.4.435 · Cited by 291
Creatine supplementation during resistance training in older adults - a meta-analysis
DEVRIES, M. C., & PHILLIPS, S. M. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000220 · Cited by 239
Chilibeck, P., Kaviani, M., Candow, D., & Zello, G. A. (2017) · Open Access Journal of Sports Medicine · doi:10.2147/oajsm.s123529 · Cited by 235
Self-citationCreatine supplementation combined with resistance training in older men
CHRUSCH, M. J., CHILIBECK, P. D., CHAD, K. E., SHAWN DAVISON, K., & BURKE, D. G. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200112000-00021 · Cited by 233
Self-citationLow-Dose Creatine Combined with Protein during Resistance Training in Older Men
CANDOW, D. G., LITTLE, J. P., CHILIBECK, P. D., ABEYSEKARA, S., ZELLO, G. A., KAZACHKOV, M., CORNISH, S. M., & YU, P. H. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318176b310 · Cited by 168
Self-citationCandow, D. G., Forbes, S. C., Chilibeck, P. D., Cornish, S. M., Antonio, J., & Kreider, R. B. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040488 · Cited by 149
Self-citationBeneficial effects of creatine supplementation in dystrophic patients
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Candow, D. G., Forbes, S. C., Chilibeck, P. D., Cornish, S. M., Antonio, J., & Kreider, R. B. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00124 · Cited by 89
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Cited by
Creatine for exercise and sports performance, with recovery considerations for healthy populations
Wax, B., Kerksick, C. M., Jagim, A. R., Mayo, J. J., Lyons, B. C., & Kreider, R. B. (2021) · Nutrients · doi:10.3390/nu13061915 · Cited by 182
Burke, R., Piñero, A., Coleman, M., Mohan, A., Sapuppo, M., Augustin, F., Aragon, A. A., Candow, D. G., Forbes, S. C., Swinton, P., et al. (2023) · Nutrients · doi:10.3390/nu15092116 · Cited by 80
Self-citationCreatine monohydrate supplementation for older adults and clinical populations
Candow, D. G., Ostojic, S. M., Chilibeck, P. D., Longobardi, I., Gualano, B., Tarnopolsky, M. A., Wallimann, T., Moriarty, T., Kreider, R. B., Forbes, S. C., et al. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2534130 · Cited by 43
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Metadata
- Authors
- Candow, D. G., Chilibeck, P. D., Gordon, J., Vogt, E., Landeryou, T., Kaviani, M., & Paus-Jensen, L.
- Affiliations
- University of Regina, Regina, Canada
- University of Saskatchewan, Saskatoon, Canada
- Acadia University, Wolfville, Canada
- ORCID
- Candow, Darren G
- Venue
- Nutrition and Health
- Publisher
- SAGE Publications
- Published
- 2020-11-24
- Volume
- 27
- Issue
- 2
- Pages
- 151-159
- ISSN
- 0260-1060
- 2047-945X
- Cited by
- 31
- References
- 13
- Language
- en
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
- Funders
- Saskatchewan Health Research Foundation
- Canada Foundation for Innovation
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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