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Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests
Abstract
A detailed report is presented on the performance of the embryonic stem cell test (EST) in a European Centre for the Validation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryotoxicity. Twenty coded test chemicals, classified as non-embryotoxic, weakly embryotoxic or strongly embryotoxic on the basis of their in vivo effects in animals and/or humans, were tested in four laboratories. The outcome showed that the EST can be considered to be a scientifically validated test, which is ready for consideration for use in assessing the embryotoxic potentials of chemicals for regulatory purposes.
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Citations
Cited by
The validated embryonic stem cell test to predict embryotoxicity in vitro
Seiler, A. E. M., & Spielmann, H. (2011) · Nature Protocols · doi:10.1038/nprot.2011.348 · Cited by 276
Self-citationAdvanced human developmental toxicity and teratogenicity assessment using human organoid models
Li, M., Gong, J., Gao, L., Zou, T., Kang, J., & Xu, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113429 · Cited by 84
The human embryonic stem cell-derived cardiomyocyte as a pharmacological model
Harding, S. E., Ali, N. N., Brito-Martins, M., & Gorelik, J. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.008 · Cited by 84
Li, L., Zhang, X., Wang, L., Chai, Z., Shen, X., Zhang, Z., & Liu, C. (2015) · Journal of Diabetes · doi:10.1111/1753-0407.12251 · Cited by 8
Metadata
- Authors
- Genschow, E., Spielmann, H., Scholz, G., Pohl, I., Seiler, A., Clemann, N., Bremer, S., & Becker, K.
- Venue
- Alternatives to Laboratory Animals
- Publisher
- SAGE Publications
- Published
- 2004-09
- Volume
- 32
- Issue
- 3
- Pages
- 209-244
- ISSN
- 0261-1929 (ISSN-L)
- 2632-3559
- OpenAlex
- W27814405
- Cited by
- 339
- References
- 0
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests. https://app.cochat.ai/papers/10.1177/026119290403200305
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- Genschow, E., Spielmann, H., Scholz, G., Pohl, I., Seiler, A., Clemann, N., Bremer, S., & Becker, K. (2004). Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests. Alternatives to Laboratory Animals. https://doi.org/10.1177/026119290403200305
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