The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests
Abstract
Abstract Current literature suggests involvement of nicotinic acetylcholine receptors (nAChRs) in major depression. However, it is controversial whether the antidepressant-like effect of nAChR modulation is induced by activation, desensitization or inhibition of central nAChRs. In addition, the specific nAChR subtype/s involved remains unknown. In this study, we systematically compared the effects of non-selective and selective nicotinic agonists and antagonists in two different tests for antidepressant effects in mice: the tail suspension test and the forced swim test. Compounds: nicotine, RJR-2403 (α4β2-selective agonist), PNU-282987 (α7-selective agonist), mecamylamine (non-selective antagonist), dihydro-β-erythroidine (DHβE; α4β2-selective antagonist), methyllycaconitine (MLA; α7-selective antagonist) and hexamethonium (non-brain-penetrant non-selective antagonist). All compounds were tested in a locomotor activity paradigm to rule out non-specific stimulant effects. The data show that blockade of nAChRs with mecamylamine, or selective antagonism of α4β2 or α7 nAChRs with DHβE or MLA, respectively, has antidepressant-like effects. These effects were not confounded by motor stimulation. Hexamethonium did not show antidepressant-like activity, supporting the involvement of central nAChRs. At the dose levels tested, none of the nAChR agonists displayed antidepressant-like profiles. In conclusion, antagonism of central α4β2 and/or α7 nAChRs induced antidepressant-like effects in mice. A strategy involving antagonism of central nAChRs could potentially lead to the development of novel antidepressant therapeutics.
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“the nicotinic antagonist mecamylamine has antidepressantlike effects in mice (Caldarone et al. 2004;Rabenstein et al. 2006;Andreasen et al. 2009)”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Andreasen et al. 2009
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Cites
The tail suspension test: A new method for screening antidepressants in mice
Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534
Behavioral despair in mice: a primary screening test for antidepressants.
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,320
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372
Dieting and binging: A causal analysis.
Polivy, J., & Herman, C. P. (1985) · American Psychologist · doi:10.1037//0003-066x.40.2.193 · Cited by 1,279
Smoking, smoking cessation, and major depression
Glassman, A. H. (1990) · JAMA · doi:10.1001/jama.1990.03450120058029 · Cited by 1,207
Guidelines on nicotine dose selection for in vivo research
Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824
Smoking and Major Depression: A Causal Analysis
Kendler, K. S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820130038007 · Cited by 792
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
Trullas, R., & Skolnick, P. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90204-j · Cited by 785
Neurobiological similarities in depression and drug dependence: a self-medication hypothesis
Markou, A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00113-9 · Cited by 767
Different data from different labs: Lessons from studies of gene–environment interaction
Wahłsten, D., Metten, P., Phillips, T. J., Boehm, S. L., Burkhart‐Kasch, S., Dorow, J. D., Doerksen, S., Downing, C., Fogarty, J., Rodd‐Henricks, K., et al. (2002) · Journal of Neurobiology · doi:10.1002/neu.10173 · Cited by 500
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- Porsolt RD, 1977, Arch Int Pharmacodyn Ther, 229, 327
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Wang, C., Li, R., Wu, Y., Hong, Z., Huang, S., Ye, Y., Tang, W., Yang, X., & Gan, D. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111177
The mechanism of Phosphatidylethanolamine-Binding Protein 1 in Neuro-Related Diseases
Mu, Y., Li, X., Yuan, Y., Meng, F., Xiong, H., Zhou, Z., Wu, L., Yang, X., Zhang, S., Chen, C., et al. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02616-8
BindingDB (2020) · UC San Diego · doi:10.7270/q2668gpb
Metadata
- Authors
- Andreasen, J., Olsen, G., Wiborg, O., & Redrobe, J.
- Affiliations
- NeuroSearch (Denmark) (DK)
- Department of Biological Psychiatry, Psychiatric Hospital, Aarhus, Denmark
- Corresponding author
- Andreasen, JT
- ORCID
- Wiborg, O
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2008-06-26
- Volume
- 23
- Issue
- 7
- Pages
- 797-804
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2140936957
- Cited by
- 101
- References
- 48
- Citations by year
- 2026: 5 · 2025: 2 · 2023: 5 · 2022: 1 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 9 · 2017: 2 · 2016: 1 · 2015: 9 · 2014: 8 · 2013: 7 · 2012: 7
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotinic acetylcholine receptors, antidepressant-like effects, major depressive disorder, nAChR antagonists, nicotinic agonists, alpha4beta2 nAChR, alpha7 nAChR, mecamylamine, dihydro-beta-erythroidine, methyllycaconitine, nicotine, PNU-282987, forced swim test, tail suspension test, locomotor activity, central nervous system
- MeSH terms
- Reboxetine, Animals, Antidepressive Agents, Behavior, Animal, Depression, Disease Models, Animal, Female, Mice, Inbred Strains, Morpholines, Motor Activity, Citalopram, Nicotinic Agonists, Nicotinic Antagonists, Mice
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