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Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice
Open accessAbstract
Psilocin (4-hydroxy- N, N-dimethyltryptamine) is a hallucinogen that acts as an agonist at 5-HT 1A , 5-HT 2A , and 5-HT 2C receptors. Psilocin is the active metabolite of psilocybin, a hallucinogen that is currently being investigated clinically as a potential therapeutic agent. In the present investigation, we used a combination of genetic and pharmacological approaches to identify the serotonin (5-HT) receptor subtypes responsible for mediating the effects of psilocin on head twitch response (HTR) and the behavioral pattern monitor (BPM) in C57BL/6J mice. We also compared the effects of psilocin with those of the putative 5-HT 2C receptor-selective agonist 1-methylpsilocin and the hallucinogen and non-selective serotonin receptor agonist 5-methoxy- N, N-dimethyltryptamine (5-MeO-DMT). Psilocin, 1-methylpsilocin, and 5-MeO-DMT induced the HTR, effects that were absent in mice lacking the 5-HT 2A receptor gene. When tested in the BPM, psilocin decreased locomotor activity, holepoking, and time spent in the center of the chamber, effects that were blocked by the selective 5-HT 1A antagonist WAY-100635 but were not altered by the selective 5-HT 2C antagonist SB 242,084 or by 5-HT 2A receptor gene deletion. 5-MeO-DMT produced similar effects when tested in the BPM, and the action of 5-MeO-DMT was significantly attenuated by WAY-100635. Psilocin and 5-MeO-DMT also decreased the linearity of locomotor paths, effects that were mediated by 5-HT 2C and 5-HT 1A receptors, respectively. In contrast to psilocin and 5-MeO-DMT, 1-methylpsilocin (0.6–9.6 mg/kg) was completely inactive in the BPM. These findings confirm that psilocin acts as an agonist at 5-HT 1A , 5-HT 2A , and 5-HT 2C receptors in mice, whereas the behavioral effects of 1-methylpsilocin indicate that this compound is acting at 5-HT 2A sites but is inactive at the 5-HT 1A receptor. The fact that 1-methylpsilocin displays greater pharmacological selectivity than psilocin indicates that 1-methylpsilocin represents a potentially useful alternative to psilocybin for development as a potential therapeutic agent.
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“Psilocybin, a classical psychedelic, can play its antidepressant roles by activating 5-HT 2A receptors (5-HT 2A R). 385”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [385]
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Citations
Cites
Griffiths, R. R., Richards, W. A., McCann, U., & Jesse, R. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0457-5 · Cited by 1,684 · cited 1×
“In recent years, a number of studies have examined the effects of psilocybin in human volunteers (Carter et al., 2004, 2005b; Gouzoulis-Mayfrank et al., 1998, 1999; Griffiths et al., 2006; Umbricht et al., 2003; Vollenweider et al., 1997, 2007; Wittmann et al., 2007).”
Nichols, D. E. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.11.002 · Cited by 1,211
Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer
Grob, C. S., Danforth, A. L., Chopra, G. S., Hagerty, M., McKay, C. R., Halberstadt, A. L., & Greer, G. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.116 · Cited by 1,206
Self-citationPsilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
Vollenweider, F. X., Vollenweider-Scherpenhuyzen, M. F. I., Bäbler, A., Vogel, H., & Hell, D. (1998) · NeuroReport · doi:10.1097/00001756-199812010-00024 · Cited by 1,018
González-Maeso, J., Weisstaub, N. V., Zhou, M., Chan, P., Ivic, L., Ang, R., Lira, A., Bradley-Moore, M., Ge, Y., Zhou, Q., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.008 · Cited by 925
Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder
Moreno, F. A., Wiegand, C. B., Taitano, E. K., & Delgado, P. L. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1110 · Cited by 789
Vollenweider, F. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00246-1 · Cited by 444
Lucki, I., Nobler, M. S., & Frazer, A. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21483-5 · Cited by 305
González-Maeso, J., Yuen, T., Ebersole, B. J., Wurmbach, E., Lira, A., Zhou, M., Weisstaub, N., Hen, R., Gingrich, J. A., & Sealfon, S. C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08836.2003 · Cited by 297
A possible correlation between drug-induced hallucinations in man and a behavioural response in mice
CORNE, S. J., & Pickering, R. W. (1967) · Psychopharmacology · doi:10.1007/bf00401509 · Cited by 271
Encyclopedia of Behavioral Neuroscience
(2011) · Choice Reviews Online · doi:10.5860/choice.48-5432 · Cited by 266
Human psychopharmacology of N,N-dimethyltryptamine
Strassman, R. J. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00081-2 · Cited by 261
Effects of psilocybin on time perception and temporal control of behaviour in humans
Wittmann, M., Carter, O. L., Hasler, F., Cahn, B. R., Grimberg, U., Spring, P., Hell, D., Flohr, H., & Vollenweider, F. X. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106065859 · Cited by 253
Differential effects of 5-hydroxytryptamine1A selective drugs on the 5-HT behavioral syndrome
Smith, L. M., & Peroutka, S. J. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90477-6 · Cited by 245
Handbook of the Behavioral Neurobiology of Serotonin
(2010) · Handbook of behavioral neuroscience · doi:10.1016/c2009-0-01827-3 · Cited by 243
Do functional relationships exist between 5-HT1A and 5-HT2 receptors?
Darmani, N. A., Martin, B. R., Pandey, U., & Glennon, R. A. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90098-3 · Cited by 243
Carter, O. L., Burr, D. C., Pettigrew, J. D., Wallis, G. M., Hasler, F., & Vollenweider, F. X. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/089892905774597191 · Cited by 234
Hasler, F., Bourquin, D., Brenneisen, R., Bär, T., & Vollenweider, F. X. (1997) · Pharmaceutica Acta Helvetiae · doi:10.1016/s0031-6865(97)00014-9 · Cited by 234
Multivariate assessment of locomotor behavior: Pharmacological and behavioral analyses
Geyer, M. A., Russo, P. V., & Masten, V. L. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90266-2 · Cited by 215
Self-citationA Reverse-Translational Study of Dysfunctional Exploration in Psychiatric Disorders
Perry, W., Minassian, A., Paulus, M. P., Young, J. W., Kincaid, M. J., Ferguson, E. J., Henry, B. L., Zhuang, X., Masten, V. L., Sharp, R. F., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.58 · Cited by 200
Self-citationDifferential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes
McKenna, D. J., Repke, D. B., Lo, L., & Peroutka, S. J. (1990) · Neuropharmacology · doi:10.1016/0028-3908(90)90001-8 · Cited by 195
Umbricht, D., Vollenweider, F. X., Schmid, L., Grübel, C., Skrabo, A., Huber, T., & Koller, R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300005 · Cited by 187
5-HT2A and 5-HT2C Receptors Exert Opposing Effects on Locomotor Activity in Mice
Halberstadt, A. L., van der Heijden, I., Ruderman, M. A., Risbrough, V. B., Gingrich, J. A., Geyer, M. A., & Powell, S. B. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.29 · Cited by 179
Self-citationSelective activation of 5HT1A receptors induces lower lip retraction in the rat
Berendsen, H. H. G., Jenck, F., & Broekkamp, C. L. E. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90477-2 · Cited by 161
Vollenweider, F., Csomor, P., Knappe, B., Geyer, M., & Quednow, B. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301324 · Cited by 159
Self-citationHallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex
Pierce, P. A., & Peroutka, S. J. (1989) · Psychopharmacology · doi:10.1007/bf00443425 · Cited by 152
Psilocybin links binocular rivalry switch rate to attention and subjective arousal levels in humans
Carter, O. L., Hasler, F., Pettigrew, J. D., Wallis, G. M., Liu, G. B., & Vollenweider, F. X. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0930-9 · Cited by 146
Gouzoulis‐Mayfrank, E., Thelen, B., Habermeyer, E., Kunert, H. J., Kovar, K. ‐., Lindenblatt, H., Hermle, L., Spitzer, M., & Sass, H. (1999) · Psychopharmacology · doi:10.1007/s002130050860 · Cited by 145
Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats
Fantegrossi, W. E., Harrington, A. W., Kiessel, C. L., Eckler, J. R., Rabin, R. A., Winter, J. C., Coop, A., Rice, K. C., & Woods, J. H. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.12.015 · Cited by 145
Tricklebank, M. D., Forler, C., Middlemiss, D. N., & Fozard, J. R. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90467-4 · Cited by 141
A temporal and spatial scaling hypothesis for the behavioral effects of psychostimulants
Paulus, M. P., & Geyer, M. A. (1991) · Psychopharmacology · doi:10.1007/bf02244547 · Cited by 134
Self-citationEffect of ring fluorination on the pharmacology of hallucinogenic tryptamines
Blair, J. B., Kurrasch-Orbaugh, D., Marona-Lewicka, D., Cumbay, M. G., Watts, V. J., Barker, E. L., & Nichols, D. E. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000339w · Cited by 131 · cited 5×
“Indoleamines, such as lysergic acid diethylamide (LSD), psilocin, N,N-dimethyltryptamine (DMT), and 5-methoxy-DMT (5-MeO-DMT) are non-selective serotonin (5-HT) receptor agonists that bind to 5-HT1A, 5-HT2A, and 5-HT2C receptors with moderateto-high affinity (Blair et al., 2000; McKenna et al., 1990; Pierce and Perout…”
BackgroundInfluentialCarter, O. L., Pettigrew, J. D., Hasler, F., Wallis, G. M., Liu, G. B., Hell, D., & Vollenweider, F. X. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300621 · Cited by 118
Modulation of 5-HT2A receptor-mediated head-twitch behaviour in the rat by 5-HT2C receptor agonists
Vickers, S. P., Easton, N., Malcolm, C., Allen, N. H., Porter, R. H., Bickerdike, M. J., & Kennett, G. A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00552-4 · Cited by 113
Johnson, M. P., Loncharich, R. J., Baez, M., & Nelson, D. L. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09924-9 · Cited by 104
Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents
Rosenzweig-Lipson, S. J., Sabb, A. L., Stack, G., Mitchell, P., Lucki, I., Malberg, J. E., Grauer, S. M., Brennan, J. A., Cryan, J. F., Rizzo, S. J. S., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0710-6 · Cited by 102
Risbrough, V. B., Masten, V. L., Caldwell, S., Paulus, M. P., Low, M. J., & Geyer, M. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301161 · Cited by 102
Self-citationHorita, A., & Weber, L. J. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90124-1 · Cited by 101
5HT-2 mediation of acute behavioral effects of hallucinogens in rats
Wing, L. L., Tapson, G. S., & Geyer, M. A. (1990) · Psychopharmacology · doi:10.1007/bf02244617 · Cited by 97
Self-citationKrebs-Thomson, K., Ruiz, E. M., Masten, V. L., Buell, M. R., & Geyer, M. A. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0566-1 · Cited by 95
Self-citationKrebs-Thomson, K. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00164-4 · Cited by 87
Psilocybin impairs high-level but not low-level motion perception
Carter, O. L., Pettigrew, J. D., Burr, D. C., Alais, D., Hasler, F., & Vollenweider, F. X. (2004) · Neuroreport · doi:10.1097/00001756-200408260-00023 · Cited by 84
Hallucinogen-induced relief of obsessions and compulsions
Moreno, F., & Delgado, P. L. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.1037b · Cited by 81
Gouzoulis‐Mayfrank, E., Heekeren, K., Thelen, B., Lindenblatt, H., Kovar, K. ‐., Sass, H., & Geyer, M. A. (1998) · Behavioural Pharmacology · doi:10.1097/00008877-199811000-00011 · Cited by 80
Self-citationThe Paradox of 5-Methoxy-N,N-Dimethyltryptamine
Winter, J. C., Filipink, R. A., Timineri, D. M., Helsley, S., & Rabin, R. A. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00178-1 · Cited by 79
SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist
Sard, H., Kumaran, G., Morency, C., Roth, B. L., Compton-Toth, B. A., He, P., & Shuster, L. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.06.104 · Cited by 77
Psilocybin-induced stimulus control in the rat
Winter, J. C., Rice, K. C., Amorosi, D. J., & Rabin, R. A. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.06.003 · Cited by 75
Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats
Fantegrossi, W. E., Harrington, A. W., Eckler, J. R., Arshad, S., Rabin, R. A., Winter, J. C., Coop, A., Rice, K. C., & Woods, J. H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0009-4 · Cited by 74
Fantegrossi, W. E., Reissig, C. J., KATZ, E., Yarosh, H. L., Rice, K. C., & WINTER, J. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.09.007 · Cited by 72
Spencer, D. G., Gläser, T., & Traber, J. (1987) · Psychopharmacology · doi:10.1007/bf00179927 · Cited by 69
A characteristic effect of hallucinogens on investigatory responding in rats
Geyer, M. A., Light, R. K., Rose, G. J., Petersen, L. R., Horwitt, D. D., Adams, L. M., & Hawkins, R. L. (1979) · Psychopharmacology · doi:10.1007/bf00491975 · Cited by 57
Self-citationMittman, S. M., & Geyer, M. A. (1991) · Psychopharmacology · doi:10.1007/bf02316866 · Cited by 50
Self-citationPaulus, M. P., & Geyer, M. A. (1991) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(91)90018-v · Cited by 48
Self-citationDephosphorylation of Psilocybin to Psilocin by Alkaline Phosphatase
Horita, A., & Weber, L. J. (1961) · Experimental Biology and Medicine · doi:10.3181/00379727-106-26228 · Cited by 46
Halberstadt, A. L., Buell, M. R., Masten, V. L., Risbrough, V. B., & Geyer, M. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1247-z · Cited by 45
Self-citationAssessment of relative efficacies of 5-HT1A receptor ligands by means of in vivo animal models
Sánchez, C., Arnt, J., & Moltzen, E. K. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00621-8 · Cited by 40
Krebs-Thomson, K., & Geyer, M. A. (1996) · PubMed · Cited by 38
Self-citationEffects of DOM and DMT in a proposed animal model of hallucinogenic activity
Adams, L. M., & Geyer, M. A. (1985) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(85)90074-0 · Cited by 37
Self-citationBehavioral effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rats and mice
Yamamoto, T., & Ueki, S. (1975) · European Journal of Pharmacology · doi:10.1016/0014-2999(75)90278-2 · Cited by 36
Cross-tolerance studies of serotonin receptors involved in behavioral effects of LSD in rats
Krebs-Thomson, K., & Geyer, M. A. (1994) · Psychopharmacology · doi:10.1007/bf02245219 · Cited by 27
Self-citationSerotonin and Serotonin Receptors in Hallucinogen Action
Halberstadt, A. L., & Nichols, D. E. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70103-x · Cited by 26
Self-citationHandling of psilocybin and psilocin by everted sacs of rat jejunum and colon.
Eivindvik, K., Rasmussen, K. E., & Sund, R. B. (1989) · PubMed · Cited by 26
5-HT1A and 5-HT2 receptors mediate discrete behaviors in the Mongolian Gerbil
Eison, A. S., & Wright, R. N. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90649-z · Cited by 25
Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity
Li, J., Rice, K. C., & France, C. P. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3281f19ca0 · Cited by 19
Halberstadt, A. L., & Geyer, M. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-045396-5.00075-0 · Cited by 7
Self-citation
Research works printed but not linked: 3
- Eivindvik K, 1989, Acta Pharm Nord, 1, 295
- Grob CS, 2010, Arch Gen Psychiatry
- Krebs-Thomson K, 1996, Behav Pharmacol, 7, 551
Cited by
Sorted by citations
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762
Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,244
“385 Thus, to block the 5-HT 2A R can not produce the antidepressant effects of psilocybin, only induce the hallucinogenic-like behaviors in mice.”
BackgroundPsilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Shao, L.-X., Liao, C., Gregg, I., Davoudian, P. A., Savalia, N. K., Delagarza, K., & Kwan, A. C. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.008 · Cited by 626
Johnson, M. W., Hendricks, P. S., Barrett, F. S., & Griffiths, R. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.010 · Cited by 506
Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens
Halberstadt, A. L., & Geyer, M. A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.017 · Cited by 435
Self-citation
Metadata
- Authors
- Halberstadt, A. L., Koedood, L., Powell, S. B., & Geyer, M. A.
- Affiliations
- Department of Psychiatry, University of California, La Jolla, CA, USA.
- Corresponding author
- Geyer, Mark A
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2010-12-08
- Volume
- 25
- Issue
- 11
- Pages
- 1548-1561
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- PMC
- PMC3531560
- OpenAlex
- W2107441654
- Cited by
- 213
- References
- 65
- Citations by year
- 2026: 24 · 2025: 32 · 2024: 31 · 2023: 20 · 2022: 18 · 2021: 8 · 2020: 11 · 2019: 9 · 2018: 13 · 2017: 5 · 2016: 10 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 4
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of California, San Diego
- National Institute of Mental Health
- National Institute on Drug Abuse (F32DA025412, R01DA002925)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- psilocin, psilocybin, 5-MeO-DMT, serotonin receptors, 5-HT1A receptor, 5-HT2A receptor, 5-HT2C receptor, head-twitch response, locomotor activity, WAY-100635, SB242084, receptor selectivity, hallucinogens
- MeSH terms
- Animals, Behavior, Hallucinogens, Male, Methoxydimethyltryptamines, Mice, Inbred C57BL, Motor Activity, Piperazines, Psilocybin, Pyridines, Receptors, Serotonin, Serotonin Antagonists, Mice, Knockout, Mice
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