The capillary bed offers the largest hemodynamic resistance to the cortical blood supply
Open accessAbstract
The cortical angioarchitecture is a key factor in controlling cerebral blood flow and oxygen metabolism. Difficulties in imaging the complex microanatomy of the cortex have so far restricted insight about blood flow distribution in the microcirculation. A new methodology combining advanced microscopy data with large scale hemodynamic simulations enabled us to quantify the effect of the angioarchitecture on the cerebral microcirculation. High-resolution images of the mouse primary somatosensory cortex were input into with a comprehensive computational model of cerebral perfusion and oxygen supply ranging from the pial vessels to individual brain cells. Simulations of blood flow, hematocrit and oxygen tension show that the wide variation of hemodynamic states in the tortuous, randomly organized capillary bed is responsible for relatively uniform cortical tissue perfusion and oxygenation. Computational analysis of microcirculatory blood flow and pressure drops further indicates that the capillary bed, including capillaries adjacent to feeding arterioles (d < 10 µm), are the largest contributors to hydraulic resistance.
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The majority of the vascular resistance within the brain is located in capillaries.
“the majority of the vascular resistance within the brain is located in capillaries (16).”
From Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes (2019) · cites this paper as [16]
Capillaries provide 57% of the total vascular resistance in the brain parenchyma.
“Since the capillaries provide 57% of the total vascular resistance in the brain parenchyma (16), and the diameter of arterioles and venules is not changed (Fig. 5H), it follows that, if the pressure is fixed at the pial end of penetrating arterioles and venules, then cerebral blood flow will be decreased by 58% (calculated as (43%+57%)/(43%+3.4x57%)).”
From Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes (2019) · cites this paper as [16]
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References 88 · Cited by 252
Research works printed but not linked: 2
- [81]Xu K, Radhakrishnan K, Serhal A, et al. In: JC LaManna (ed.) Oxygen transport to tissue XXXII, Springer Science+Business Media, 2011.
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- Authors
- Gould, I. G., Tsai, P., Kleinfeld, D., & Linninger, A.
- Affiliations
- University of Illinois Chicago (US)
- University of California San Diego (US)
- Corresponding author
- Linninger, Andreas
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2016-10-10
- Volume
- 37
- Issue
- 1
- Pages
- 52-68
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- PMC
- PMC5363755
- OpenAlex
- W2531712355
- Cited by
- 252
- References
- 88
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 27 · 2023: 30 · 2022: 23 · 2021: 43 · 2020: 26 · 2019: 27 · 2018: 21 · 2017: 13
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (DP1OD006831)
- National Institute of Neurological Disorders and Stroke (DP1NS082097, R35NS097265)
- National Institute of Biomedical Imaging and Bioengineering (R01EB003832)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- cerebral microcirculation, capillary network, cerebral blood flow, oxygen supply, primary somatosensory cortex, hematocrit, oxygen partial pressure, pressure drop, tissue perfusion, mouse brain
- MeSH terms
- Animals, Blood Pressure, Capillaries, Capillary Resistance, Cerebral Cortex, Cerebrovascular Circulation, Hemodynamics, Microcirculation, Models, Cardiovascular, Oxygen, Mice
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