The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Distribution characteristics of cells in splenomegaly due to hepatitis B-related cirrhotic portal hypertension and their clinical importance
Open accessAbstract
Objectives: To investigate peripheral cytopenia in patients with splenomegaly due to hepatitis B-related cirrhotic portal hypertension (HBRCPH) by comparing blood cell counts from enlarged spleens with peripheral blood. Methods: This prospective study involved patients undergoing splenectomy at the Nangfang Hospital from June 2013 to December 2015. Blood cell counts from peripheral blood were compared with those from splenic blood taken during splenectomies. Results: Clinical data were available from 30 patients. White blood cell (WBC), red blood cell (RBC) and platelet counts were statistically significantly lower in peripheral blood compared with splenic blood. After splenectomy, peripheral blood cell counts increased significantly compared with pre-operative levels. Platelet and WBC counts in the lower spleen were significantly higher than those in the porta lienis (middle segment) and upper spleen. Conclusions: In patients with splenomegaly due to HBRCPH, the counts of three blood cell lineages were significantly higher in the spleen than in peripheral blood. Splenectomy can aid the return of peripheral blood cell counts to normal levels. The most significant retention of platelets and WBCs occurred in the lower spleen which may be useful information for surgeons performing partial splenectomies.
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![Figure 1. The resected spleen was divided into three segments (upper, porta lienis [middle] and lower).](/paper-figures/e29db6dd3f604ebd9e5910e0fa34591e/distribution-characteristics-of-cells-in-splenomegaly-due-to-hepatitis-b-related-figure-1.jpg)
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“WBC levels increased significantly compared with the MCD group, indicating the relief of blood cell entrapment related to splenomegaly caused by increased portal vein pressure,[ 30 ] which also demonstrated the therapeutic effect of MUA/Y.”
From An Autologous Macrophage‐Based Phenotypic Transformation‐Collagen Degradation System Treating Advanced Liver Fibrosis (2024) · cites this paper as [30]
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Cites
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Spleen-targeted delivery systems and strategies for spleen-related diseases
Huang, Z., Sun, K., Luo, Z., Zhang, J., Zhou, H., Yin, H., Liang, Z., & You, J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.007 · Cited by 56
Duan, B., Liu, Y., Li, X., Han, M., Yu, H., Hong, H., Zhang, L., Xing, L., & Jiang, H. (2024) · Advanced Science · doi:10.1002/advs.202306899 · Cited by 38
Soares, G. A., Pereira, G. M., Romualdo, G. R., Biasotti, G. G. D. A., Stoppa, E. G., Bakuzis, A. F., Baffa, O., Barbisan, L. F., & Miranda, J. R. D. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091907 · Cited by 13
ESPLENOMEGALIA: PRINCIPAIS CAUSAS EM UMA REVISÃO DA LITERATURA
Soares, P. H. L., Borges, G. M., Alves, M. L. F. S., Costa, L. M., & Vieira, C. C. L. D. R. (2024) · Revista Ibero-Americana de Humanidades, Ciências e Educação · doi:10.51891/rease.v10i5.14336 · Cited by 1
Al-Salem, A. H. (2023) · Springer eBooks · doi:10.1007/978-981-99-6191-7_18
Metadata
- Authors
- Han, X., Lv, Y., Li, Y., Deng, J., Qiu, Q., Liu, N., Zhao, S., & Liao, C.
- Affiliations
- Nanfang Hospital (CN)
- Department of General Surgery, Hainan Provincial People’s Hospital, Haikou 570311, China.
- Department of Reproductive, Maternal and Child Care of Hainan Province, Haikou 571000, China
- Department of Liver Vascular Surgery, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China.
- Corresponding author
- Lv, Yunfu
- Venue
- Journal of International Medical Research
- Publisher
- SAGE Publications
- Published
- 2018-05-20
- Volume
- 46
- Issue
- 7
- Pages
- 2633-2640
- ISSN
- 0300-0605 (ISSN-L)
- 1473-2300
- PMC
- PMC6124259
- OpenAlex
- W2805021776
- Cited by
- 5
- References
- 21
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of International Medical Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- the Special Fund for Scientific and Technological Cooperation of Hainan, China (KJHZ2015-28)
- the Hainan provincial key scientific and technological research and development projects (ZDYF2016158)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- splenomegaly, hepatitis B cirrhosis, portal hypertension, peripheral cytopenia, splenectomy, platelet retention, red blood cell count, partial splenectomy
- MeSH terms
- Adult, Blood Cell Count, Female, Hepatitis B, Humans, Hypertension, Portal, Liver Cirrhosis, Male, Middle Aged, Pilot Projects, Prospective Studies, Splenomegaly, Young Adult
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- Han, X., Lv, Y., Li, Y., Deng, J., Qiu, Q., Liu, N., Zhao, S., & Liao, C. (2018). Distribution characteristics of cells in splenomegaly due to hepatitis B-related cirrhotic portal hypertension and their clinical importance. Journal of International Medical Research. https://doi.org/10.1177/0300060518767550
