Use of Fibrin Adhesive to Reduce Post-Surgical Adhesion Reformation in Rabbits
Open accessAbstract
Following surgery on fallopian tubes, the development of adhesions is a natural consequence of wound healing and may result in infertility. Using a rabbit model, we evaluated the anti-adhesive properties of a sponge-like equine collagen sheet (TachoComb®), which is coated on one side with human fibrinogen and bovine thrombin. TachoComb® is applied by affixing the sheet over the area of perforation or bleeding and acts as a haemostatic agent, capable of sealing perforations to prevent leakage. In our rabbit model, adhesions were induced by mechanical and chemical irritants during laparotomy. After a 1-month recovery period, adhesions were lysed using microsurgical techniques and TachoComb®, or physiological saline applied. Evaluation of adhesion reformation was determined after a minimum of 10 days. TachoComb® significantly reduced the area of adhesion reformation compared with rabbits treated using physiological saline only. Our study demonstrated that TachoComb® is effective not only as a haemostatic agent, but is also capable of reducing adhesion reformation.
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Use of fibrin as standalone adhesion barriers is limited because fibrin can contribute to adhesion formation.
“However, their use as standalone adhesion barriers is limited because fibrin can contribute to adhesion formation [71,72,73].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [72]
The Discussion describes a fibrin net forming after tissue injury and progressing to a mature fibrous adhesion, supporting the point that fibrin can contribute to adhesion formation. It does not say that this process limits fibrin's use as a standalone adhesion barrier; the study instead evaluates a fibrinogen- and thrombin-coated collagen sheet. (LLM, conf=0.86)
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Research works printed but not linked: 15
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Osada, H., Minai, M., Yoshida, T., & Satoh, K.
- Affiliations
- Nihon University (JP)
- ORCID
- Venue
- Journal of International Medical Research
- Publisher
- SAGE Publications
- Published
- 1999-09
- Volume
- 27
- Issue
- 5
- Pages
- 242-246
- ISSN
- 0300-0605 (ISSN-L)
- 1473-2300
- OpenAlex
- W2412198512
- Cited by
- 9
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of International Medical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- postoperative adhesions, adhesion reformation, fibrin glue, TachoComb, fibrinogen, bovine thrombin, hemostatic agents, fallopian tube surgery, laparotomy, infertility, rabbit model
- MeSH terms
- Tissue Adhesions, Animals, Cattle, Drug Combinations, Fallopian Tubes, Female, Fibrinogen, Humans, Aprotinin, Postoperative Complications, Rabbits, Thrombin
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