Clinical Evaluation of a Haemostatic and Anti-Adhesion Preparation Used to Prevent Post-Surgical Adhesion
Open accessAbstract
TachoComb® consists of equine collagen in a sponge-like form coated on one side with human fibrinogen and bovine thrombin. This product functions as a haemostatic and physical barrier to inhibit post-surgical adhesion. In this study, we investigated TachoComb® to control oozing in 16 patients who required haemostasis. Evaluation of post-surgical adhesion by second-look laparoscopy was performed at 3 months and 7 months after initial surgery. Observation via laparotomy during Caesarean section was also performed at 13 months, 3 years and 4 years after initial surgery. In all but one patient, no macroscopic evidence of TachoComb® persistence was found. Furthermore, no de novo adhesions were detected at the TachoComb® application site. We have thus demonstrated that TachoComb® can be used to control oozing haemorrhage effectively from surgical sites and can prevent adhesion formation at the application site, and may thus be an effective method of preventing adhesion-induced infertility.
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TachoSil® is a sponge-like sheet composed of equine collagen coated with human fibrinogen and bovine thrombin; when moistened, the coated side forms a fibrin barrier at the application site, enabling effective hemostasis while acting as a physical barrier to prevent postoperative adhesions.
“One of the earliest clinically evaluated hemostatic and anti-adhesion barriers was TachoSil®, a sponge-like sheet composed of equine collagen coated with human fibrinogen and bovine thrombin (Figure 3B). When moistened with saline, the coated side formed a fibrin barrier at the application site, enabling effective hemostasis while acting as a physical barrier to prevent postoperative adhesions.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [74]
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Experimental — accuracy not yet measuredIn a study involving 16 gynecological surgery patients, complete hemostasis was achieved in 87.5% of cases, and no de novo adhesions were observed at application sites upon second-look laparoscopy or laparotomy conducted up to 4 years post-operation.
“In a study involving 16 gynecological surgery patients, complete hemostasis was achieved in 87.5% of cases, and no de novo adhesions were observed at application sites upon second-look laparoscopy or laparotomy conducted up to 4 years post-operation.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [74]
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Research works printed but not linked: 22
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Osada, H., Tanaka, H., Fujii, T., Tsunoda, I., Yoshida, T., & Satoh, K.
- Affiliations
- Nihon University (JP)
- Venue
- Journal of International Medical Research
- Publisher
- SAGE Publications
- Published
- 1999-09
- Volume
- 27
- Issue
- 5
- Pages
- 247-252
- ISSN
- 0300-0605 (ISSN-L)
- 1473-2300
- OpenAlex
- W1904964687
- Cited by
- 29
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2020: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of International Medical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- TachoComb, postoperative adhesions, adhesion prevention, hemostasis, fibrinogen, bovine thrombin, second-look laparoscopy, cesarean section
- MeSH terms
- Tissue Adhesions, Adult, Drug Combinations, Female, Fibrinogen, Hemostasis, Surgical, Humans, Aprotinin, Middle Aged, Postoperative Complications, Gynecologic Surgical Procedures, Thrombin
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