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Cited by 55Estrogen and related hormone effectsBreast Cancer Treatment StudiesEffects and risks of endocrine disrupting chemicals

The DOI matches its Crossref record.

Endocrine Effects of Tamoxifen in Postmenopausal Breast Cancer Patients

Boccardo, Francesco, Guarneri, Domenico, Rubagotti, Alessandra, Casertelli, Gian Luigi, Bentivoglio, Giorgio, Conte, Nori, Campanella, Gianpaolo, Gaggero, Giuliana, Conielli, Gabriella, Zanardi, Silvia, Nicolò, Guido·1984·Tumori Journal
DOI 10.1177/030089168407000110
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Abstract

The effects of tamoxifen on plasma concentration of gonadotropins, prolactin (PRL), estrone (E1), estradiol-17β (E2), and sex hormone-binding globulin (SHBG) were studied in 40 postmenopausal breast cancer patients. In addition, the changes induced by the drug on endometrium and vaginal epithelium were investigated. After 6–8 weeks of tamoxifen treatment, a significant decrease in FSH, LH and PRL basal levels was observed, whereas the concentrations of E1 and E2 were not significantly affected. A significant increase in SHBG levels was induced by prolonged treatment with the drug. In addition, tamoxifen caused a partial estrogenization of vaginal smears, and a weak stimulatory effect on endometrium was also apparent. These findings indicate that tamoxifen produced agonistic effects on some targets and antagonistic effects on the others.

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Citations

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Research works printed but not linked: 26

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Cited by

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Metadata

Authors
Boccardo, F., Guarneri, D., Rubagotti, A., Casertelli, G. L., Bentivoglio, G., Conte, N., Campanella, G., Gaggero, G., Conielli, G., Zanardi, S., & Nicolò, G.
Affiliations
  • Istituto Nazionale per la Ricerca sul Cancro, Istituto di Oncologia dell'Università
  • University of Genoa (IT)
ORCID
Venue
Tumori Journal
Publisher
SAGE Publications
Published
1984-02
Volume
70
Issue
1
Pages
61-68
ISSN
  • 0300-8916 (ISSN-L)
  • 2038-2529
DOI
10.1177/030089168407000110
OpenAlex
W4301696168
Cited by
55
References
0
Citations by year
2022: 4 · 2018: 1 · 2015: 1 · 2012: 1
FWCI
0.75
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Tumori Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords
tamoxifen, postmenopausal breast cancer, endocrine effects, gonadotropins, follicle-stimulating hormone, luteinizing hormone, prolactin, estrone, estradiol, sex hormone-binding globulin, endometrium, vaginal epithelium, estrogenization, selective estrogen receptor modulators
MeSH terms
Aged, Breast Neoplasms, Endometrium, Female, Hormones, Humans, Mastectomy, Menopause, Middle Aged, Sex Hormone-Binding Globulin, Tamoxifen, Time Factors, Vagina

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CoChat. (2026). Citation check: Endocrine Effects of Tamoxifen in Postmenopausal Breast Cancer Patients. https://app.cochat.ai/papers/10.1177/030089168407000110
The paper
Boccardo, F., Guarneri, D., Rubagotti, A., Casertelli, G. L., Bentivoglio, G., Conte, N., Campanella, G., Gaggero, G., Conielli, G., Zanardi, S., & Nicolò, G. (1984). Endocrine Effects of Tamoxifen in Postmenopausal Breast Cancer Patients. Tumori Journal. https://doi.org/10.1177/030089168407000110

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.