The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Antimicrobial Effects of Two Anaesthetic Agents: Dexmedetomidine and Midazolam
Open accessAbstract
Some anaesthetic agents are known to inhibit microbial growth. The aim of this in vitro study was to investigate possible antimicrobial effects of two frequently used agents in intensive care units, dexmedetomidine and midazolam. Antimicrobial effect was tested on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa by broth microdilution method. Midazolam showed inhibitor and bactericidal effect on S. aureus at concentrations 256 μg.ml -1 and 512 μgml -1 respectively and on E. faecalis at concentrations 128 μg.ml 1 and 256 μg.ml -1 . Dexmedetomidine demonstrated inhibitor effect on S. aureus, E. coli and P. aeruginosa at concentrations 32 μg.ml -1 , 16 μg.ml -1 and 16 μg.ml -1 respectively. Midazolam had inhibitor and bactericidal effects on S. aureus and E. faecalis. Dexmedetomidine had only inhibitor effects on S. aureus, E. coli and P. aeruginosa. Further studies are needed to determine the antimicrobial mechanisms and clinical applications.
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“| Midazolam (promotes the action of GABA) | C. albicans, S. aureus, E. faecalis, E. coli, P. aeruginosa, A. baumanii | 95 µM-12 mM (31.25-4000 µg/mL) | Inhibits growth, hyphae formation, and biofilm growth, inhibits bacterial growth | [76-78] |”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [77]
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“| Midazolam (promotes the action of GABA) | C. albicans, S. aureus, E. faecalis, E. coli, P. aeruginosa, A. baumanii | 95 µM-12 mM (31.25-4000 µg/mL) | Inhibits growth, hyphae formation, and biofilm growth, inhibits bacterial growth | [76-78] |”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [77]
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Citations
Cites
Manual of clinical microbiology
Drasar, B. (2003) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(03)90074-5 · Cited by 2,605
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The Inhibitory Effects of Thiopental, Midazolam, and Ketamine on Human Neutrophil Functions
Nishina, K., Akamatsu, H., Mikawa, K., et al. (1998) · Anesthesia & Analgesia · doi:10.1097/00000539-199801000-00032 · Cited by 150
Lauven, P. M., Schwilden, H., Stoeckel, H., & Greenblatt, D. J. (1985) · Anesthesiology · doi:10.1097/00000542-198507000-00009 · Cited by 97
Growth of Staphylococcus aureus in Four Intravenous Anesthetics
Sosis, M. B., & Braverman, B. (1993) · Anesthesia & Analgesia · doi:10.1213/00000539-199310000-00019 · Cited by 81
Microbial Growth and Endotoxin Production in the Intravenous Anesthetic Propofol
Arduino, M. J., Bland, L. A., McAllister, S. K., Aguero, S. M., Villarino, M. E., McNeil, M. M., Jarvis, W. R., & Favero, M. S. (1991) · Infection Control and Hospital Epidemiology · doi:10.2307/30145228 · Cited by 72
Growth of Microorganisms in Propofol, Thiopental, and a 1
CROWTHER, J. A., Hrazdil, J., Jolly, D. T., Galbraith, J. C., Greacen, M., & Grace, M. (1996) · Anesthesia & Analgesia · doi:10.1097/00000539-199603000-00008 · Cited by 71
Research works printed but not linked: 4
- Clinical and Laboratory Standards Institute, 2003, Approved Standard M7-A6
- Crowther J, 1996, Anesth Analg, 82, 475
- Fazly Bazaz BS, 1983, Microbios, 37, 45
- Durak P, 2001, Acta Anaesthesiol Ital, 52, 39
Cited by
Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications
Caldara, M., & Marmiroli, N. (2021) · Pharmaceuticals · doi:10.3390/ph14090915 · Cited by 54
Metadata
- Authors
- Ayoglu, H., Kulah, C., & Turan, I.
- Affiliations
- Departments of Anesthesiology and Reanimation and Medical Microbiology, Karaelmas University School of Medicine, Zonguldak, Turkey
- Zonguldak Bülent Ecevit University (TR)
- ORCID
- Turan, I.
- Venue
- Anaesthesia and Intensive Care
- Publisher
- SAGE Publications
- Published
- 2008-09
- Volume
- 36
- Issue
- 5
- Pages
- 681-684
- ISSN
- 0310-057X (ISSN-L)
- 1448-0271
- OpenAlex
- W2413904807
- Cited by
- 21
- References
- 22
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anaesthesia and Intensive Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
- Keywords
- dexmedetomidine, midazolam, antimicrobial activity, anesthetic agents, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, bactericidal activity, intensive care unit
- MeSH terms
- Anesthetics, Anti-Infective Agents, Dose-Response Relationship, Drug, Escherichia coli, Hypnotics and Sedatives, Midazolam, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Dexmedetomidine, In Vitro Techniques
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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