The impact of chronic migraine: The Chronic Migraine Epidemiology and Outcomes (CaMEO) Study methods and baseline results
Open accessAbstract
Background: Longitudinal migraine studies have rarely assessed headache frequency and disability variation over a year. Methods: The Chronic Migraine Epidemiology and Outcomes (CaMEO) Study is a cross-sectional and longitudinal Internet study designed to characterize the course of episodic migraine (EM) and chronic migraine (CM). Participants were recruited from a Web-panel using quota sampling in an attempt to obtain a sample demographically similar to the US population. Participants who passed the screener were assessed every three months with the Core (baseline, six, and 12 months) and Snapshot (months three and nine) modules, which assessed headache frequency, headache-related disability, treatments, and treatment satisfaction. The Core also assessed resource use, health-related quality of life, and other features. One-time cross-sectional modules measured family burden, barriers to medical care, and comorbidities/endophenotypes. Results: Of 489,537 invitees, we obtained 58,418 (11.9%) usable returns including 16,789 individuals who met ICHD-3 beta migraine criteria (EM (<15 headache days/mo): n = 15,313 (91.2%); CM (≥15 headache days/mo): n = 1476 (8.8%)). At baseline, all qualified respondents ( n = 16,789) completed the Screener, Core, and Barriers to Care modules. Subsequent modules showed some attrition (Comorbidities/Endophenotypes, n = 12,810; Family Burden (Proband), n = 13,064; Family Burden (Partner), n = 4022; Family Burden (Child), n = 2140; Snapshot (three months), n = 9741; Core (six months), n = 7517; Snapshot (nine months), n = 6362; Core (12 months), n = 5915). A total of 3513 respondents (21.0%) completed all modules, and 3626 (EM: n = 3303 (21.6%); CM: n = 323 (21.9%)) completed all longitudinal assessments. Conclusions: The CaMEO Study provides cross-sectional and longitudinal data that will contribute to our understanding of the course of migraine over one year and quantify variations in headache frequency, headache-related disability, comorbidities, treatments, and familial impact.
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Current understanding of migraine burden among individuals with the highest unmet needs, specifically those experiencing ≥4 monthly migraine days and prior prophylaxis failure, is limited.
“However, the current understanding of migraine burden among individuals with the highest unmet needs, specifically those experiencing ≥4 monthly migraine days (MMDs) and prior prophylaxis failure, is limited.”
From My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed (2018) · cites this paper as [8]
No detailed assessment of the current treatment pathway, impact on work productivity, or burden associated with premonitory and postdromal phases of migraine is available in individuals experiencing ≥4 monthly migraine days who have had previous prophylactic treatments that failed and continue to experience frequent migraines.
“Specifically, no detailed assessment of the current treatment pathway, impact on work productivity, or burden associated with premonitory and postdromal phases of migraine is available in individuals experiencing ≥4 MMDs who have had previous prophylactic treatments that failed and continue to experience frequent migraines.”
From My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed (2018) · cites this paper as [8]
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References 40 · Cited by 305
Research works printed but not linked: 1
- [39]Wang SJ Wang PJ Fuh JL Comparisons of disability, quality of life, and resource use between chronic and episodic migraineurs: A clinic-based study in Taiwan. Cephalalgia 2013; 33: 171– 181. 23203506
- Authors
- Adams, A. M., Serrano, D., Buse, D. C., Reed, M. L., Marske, V., Fanning, K. M., & Lipton, R. B.
- Affiliations
- Allergan Inc., Irvine, CA, USA
- Albert Einstein College of Medicine (US)
- Vedanta Research, Chapel Hill, NC, USA
- Corresponding author
- Adams, Aubrey Manack
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2014-10-10
- Volume
- 35
- Issue
- 7
- Pages
- 563-578
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- PMC
- PMC4430584
- OpenAlex
- W2123954268
- Cited by
- 305
- References
- 40
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 38 · 2023: 29 · 2022: 45 · 2021: 35 · 2020: 43 · 2019: 29 · 2018: 12 · 2017: 14 · 2016: 14 · 2015: 6
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cephalalgia (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k23ns051409-02, 5r01ag025119-05)
- National Institute on Aging (R01-AG025119, R01AG022374, P01AG03949, P01AG003949, R01AG034119, R01AG012101, K23AG030857, R01-AG-12101)
- National Institute of Neurological Disorders and Stroke (K23NS047256, K23 NS47256, K23NS051409-01A1)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Keywords
- chronic migraine, episodic migraine, migraine epidemiology, headache frequency, headache-related disability, health-related quality of life, resource utilization (health care), barriers to medical care, family burden, comorbidities, endophenotypes, internet-based survey, attrition
- MeSH terms
- Adult, Chronic Disease, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Migraine Disorders, Treatment Outcome, Sickness Impact Profile
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