Single-walled and multiwalled carbon nanotubes induce oxidative stress in isolated rat brain mitochondria
Abstract
Single-walled carbon nanotubes (SWCNTs) and multiwalled carbon nanotubes (MWCNTs) are broadly applicable across a variety of industrial fields. Despite their usefulness in many different applications, oxidative stress-induced toxicity of SWCNTs and MWCNTs has not been widely investigated. The present study examined the effects of SWCNTs and MWCNTs on rat brain mitochondria using the 3,4 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay and indices of reactive oxygen species (ROS), based on measurements of malondialdehyde (MDA), glutathione (GSH), and mitochondrial membrane potential. Based on the MTT assay, exposure to SWCNTs and MWCNTs decreased mitochondrial survival and viability in a dose-dependent manner. Findings also indicated that MWCNTs and SWCNTs could damage mitochondrial membranes and induce the formation of ROS, as indicated by increased levels of MDA and decreased GSH content. The results of this study suggest that SWCNTs and MWCNTs likely damage brain tissue mitochondria by increasing oxidative stress and possibly activating the apoptosis pathway as well as other pathways of cytotoxicity.
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Exposure of carbon nanotubes may cause cytotoxicity in the CNS.
“exposure of CNTs may cause cytotoxicity in CNS”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [323]
Cites
Xiao, G. G., Wang, M., Li, N., Loo, J. A., & Nel, A. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306423200 · Cited by 428 · see citing works
Mesothelioma: Do asbestos and carbon nanotubes pose the same health risk?
Jaurand, M.-C. F., Renier, A., & Daubriac, J. (2009) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-6-16 · Cited by 147 · see citing works
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The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906 · see citing works
“After being injected through the tails of ICR (CD-1) mice, the NP showed signi fi cant antinociceptive effects which means loperamide was able to be transported across BBB. Frey II et al. investigated the delivery of IGF1 to CNS, con fi rming they reached CNS target sites of rats by administering a mixture of [ 125 I]-l…”
Background
- Authors
- Rasras, S., Kalantari, H., Rezaei, M., Dehghani, M. A., Zeidooni, L., Alikarami, K., Dehghani, F., & Alboghobeish, S.
- Affiliations
- Ahvaz Jundishapur University of Medical Sciences (IR)
- Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
- Tarbiat Modares University (IR)
- Shiraz University of Medical Sciences (IR)
- Corresponding author
- Alboghobeish, Soheila
- ORCID
- Venue
- Toxicology and Industrial Health
- Publisher
- SAGE Publications
- Published
- 2019-07
- Volume
- 35
- Issue
- 7
- Pages
- 497-506
- ISSN
- 0748-2337 (ISSN-L)
- 1477-0393
- OpenAlex
- W2954386283
- Cited by
- 27
- References
- 2
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 3 · 2020: 4
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Industrial Health (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the Student Research Committee of Ahvaz Jundishapur Medical Sciences University, Ahvaz, Iran.
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- single-walled carbon nanotubes, multi-walled carbon nanotubes, oxidative stress, brain mitochondria, mitochondrial toxicity, reactive oxygen species, malondialdehyde, glutathione, mitochondrial membrane potential, cytotoxicity, apoptosis
- MeSH terms
- Animals, Brain, Cell Survival, Dose-Response Relationship, Drug, Male, Mitochondria, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Nanotubes, Carbon, Rats, Membrane Potential, Mitochondrial
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