mPer1 and mPer2 Are Essential for Normal Resetting of the Circadian Clock
Open accessAbstract
Mammalian Per1 and Per2 genes are involved in the mechanism of the circadian clock and are inducible by light. A light pulse can evoke a change in the onset of wheel-running activity in mice by shifting the onset of activity to earlier times (phase advance) or later times (phase delays) thereby advancing or delaying the clock (clock resetting). To assess the role of mouse Per (mPer) genes in circadian clock resetting, mice carrying mutant mPer1 or mPer2 genes were tested for responses to a light pulse at ZT 14 and ZT 22, respectively. The authors found that mPer1 mutants did not advance and mPer2 mutants did not delay the clock. They conclude that the mammalian Per genes are not only light-responsive components of the circadian oscillator but also are involved in resetting of the circadian clock.
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mPER1 and mPER2 play multiple, nonredundant roles in circadian clock control.
“these studies indicate that mPER1 and mPER2 play multiple, nonredundant roles in circadian clock control.”
From Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. (2001) · cites this paper as Albrecht et al., 2001
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References 29 · Cited by 375
- Authors
- Albrecht, U., Zheng, B., Larkin, D., Sun, Z. S., & Lee, C. C.
- Affiliations
- Max Planck Society (DE)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- Corresponding author
- Albrecht, Urs
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 2001-04
- Volume
- 16
- Issue
- 2
- Pages
- 100-104
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W2118646967
- Cited by
- 375
- References
- 29
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 14 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 14 · 2016: 8 · 2015: 10 · 2014: 15 · 2013: 23 · 2012: 12
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- Per1, Per2, circadian clock, clock resetting, light pulses, phase advance, phase lag, wheel running, mouse mutants, light entrainment
- MeSH terms
- Animals, Circadian Rhythm, Exons, Mice, Inbred C57BL, Mutation, Nuclear Proteins, Photic Stimulation, Transcription Factors, Cell Cycle Proteins, Mice, Period Circadian Proteins
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