Chronic Clorgyline Treatment of Syrian Hamsters: An Analysis of Effects on the Circadian Pacemaker
Abstract
Clorgyline, a type A monoamine oxidase inhibitor with antidepressant properties when administered to depressed patients, is often associated with disturbances of the human sleep-wake cycle. In order to assess its effects on the mammalian circadian system, this drug was administered chronically to Syrian hamsters. It was found to affect the hamster circadian system in four specific ways. Clorgyline increased the intrinsic period of wheel-running ac tivity, altered the phase response curve to brief light pulses, altered the educed waveform of running activity in animals maintained in light-dark cycles or constant darkness, and in creased the activity-rest ratio in animals maintained in constant darkness. Our data support the interpretation that clorgyline exhibits direct or indirect input to the circadian pacemaker and alters the processing of photic information to the pacemaker.
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This risk could be increased by the administration of certain antidepressants, which have been shown to slow the oscillations of the pacemaker and to interfere with its entrainment to light-dark cycles in experimental animals, and to cause rapid cycling in certain bipolar patients.
“This risk could be increased by the administration of certain antidepressants, which have been shown to slow the oscillations of the pacemaker and to interfere with its entrainment to light–dark cycles in experimental animals, and to cause rapid cycling in certain bipolar patients27–29.”
From Bipolar mood cycles associated with lunar entrainment of a circadian rhythm (2018) · cites this paper as [27]
Some antidepressants have the demonstrated capacity to slow the intrinsic rhythm of the circadian pacemaker, thereby making it susceptible to capture by the slower-than-24-h rhythm of the lunar tidal day.
“This effect might result from the demonstrated capacity of some antidepressants to slow the intrinsic rhythm of the circadian pacemaker, thereby making it susceptible to capture by the slower-than-24-h rhythm of the lunar tidal day.”
From Bipolar mood cycles and lunar tidal cycles (2018) · cites this paper as [32]
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References 57 · Cited by 58
- Authors
- Duncan, W. C., Tamarkin, L., Sokolove, P. G., & Wehr, T. A.
- Affiliations
- National Institute of Mental Health (US)
- University of Maryland, Baltimore County (US)
- ORCID
- Wehr, Thomas A.
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 1988-12
- Volume
- 3
- Issue
- 4
- Pages
- 305-322
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W2094636083
- Cited by
- 58
- References
- 57
- Citations by year
- 2018: 1 · 2017: 1
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- clorgyline, circadian pacemaker, monoamine oxidase inhibitors, golden hamster, wheel running, phase response curve, light pulses, constant darkness, light entrainment, antidepressants, sleep-wake cycle
- MeSH terms
- Animals, Circadian Rhythm, Clorgyline, Cricetinae, Male, Mesocricetus, Motor Activity
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