Frequency of CD4+CD25 high Regulatory T Cells in the Peripheral Blood of Egyptian Children With Autism
Abstract
Autoimmunity may have a role in autism, although the origins of autoimmunity in autism are unknown. CD4 + CD25 high regulatory T cells play an important role in the establishment of immunological self-tolerance, thereby preventing autoimmunity. The authors are the first to study the frequency of CD4 + CD25 high regulatory T cells in the blood of 30 autistic and 30 age- and sex-matched healthy children. Patients with autism had significantly lower frequency of CD4 + CD25 high regulatory T cells than healthy children (P < .001). These cells were deficient in 73.3% of children with autism. Autistic patients with allergic manifestations (40%) and those with a family history of autoimmunity (53.3%) had a significantly lower frequency of CD4 + CD25 high regulatory T cells than those without (P < .01 and P < .001, respectively). In conclusion, CD4 + CD25 high regulatory T cells are deficient in many children with autism. Deficiency of these cells may contribute to autoimmunity in a subgroup of children with autism. Consequently, CD4 + CD25 high regulatory T cells could be new potential therapeutic targets in these patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A more recent report noted a decrease in CD4+CD25high regulatory T cells in children with autism.
“A more recent report noted a decrease in CD4 + CD25 high regulatory T cells in children with autism (Mostafa et al, 2010).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Mostafa et al, 2010
The citation lists haven’t been fetched yet
References 41 · Cited by 105
- Authors
- Mostafa, G. A., Al Shehab, A., & Fouad, N. R.
- Affiliations
- Ain Shams University (EG)
- Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
- Corresponding author
- Mostafa, Gehan A.
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 2009-08-27
- Volume
- 25
- Issue
- 3
- Pages
- 328-335
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- OpenAlex
- W2030771043
- Cited by
- 105
- References
- 41
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 13 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 11
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- autism spectrum disorder, regulatory T cells, CD4+CD25high T cells, autoimmunity, self-tolerance, peripheral blood, allergic symptoms, children, therapeutic target
- MeSH terms
- Autistic Disorder, Autoimmune Diseases, Child, Child, Preschool, Egypt, Family, Female, Follow-Up Studies, Humans, Hypersensitivity, Male, T-Lymphocytes, CD4 Antigens, Case-Control Studies, CD4 Lymphocyte Count, Interleukin-2 Receptor alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
