The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Evidence of the Gluten-Free and Casein-Free Diet in Autism Spectrum Disorders: A Systematic Review
Open accessAbstract
In autism spectrum disorders, many parents resort to alternative treatments and these are generally perceived as risk free. Among these, the most commonly used is the gluten-free, casein-free diet. The objective of this work was to conduct a systematic review of studies published from 1970 to date related to the gluten-free, casein-free diet in autism spectrum disorder patients. Few studies can be regarded as providing sound scientific evidence since they were blinded randomized controlled trials, and even these were based on small sample sizes, reducing their validity. We observed that the evidence on this topic is currently limited and weak. We recommend that it should be only used after the diagnosis of an intolerance or allergy to foods containing the allergens excluded in gluten-free, casein-free diets. Future research should be based on this type of design, but with larger sample sizes.
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“while other studies highlighted that the adoption of this elimination diet could decrease fiber intake [103], thus probably aggravating the GI problems.”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [103]
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Cited by
Sorted by citations
Identification, Evaluation, and Management of Children With Autism Spectrum Disorder
Hyman, S. L., Levy, S. E., Myers, S. M., COUNCIL ON CHILDREN WITH DISABILITIES, S. O. D. A. B. P., Kuo, D. Z., Apkon, S., Davidson, L. F., Ellerbeck, K. A., Foster, J. E. A., Noritz, G. H., et al. (2020) · Pediatrics · doi:10.1542/peds.2019-3447 · Cited by 1,798
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Autism Spectrum Disorders and the Gut Microbiota
Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484
Autism spectrum disorders and intestinal microbiota
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“A recent systematic review concluded that the evidence to support a gluten-free, casein-free diet is limited and weak, considering that dietary restrictions might be responsible for further social withdrawal and integration, in addition to potential adverse clinical effects.(53) Elimination diets for ASD patients shou…”
BackgroundAutism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions
Ristori, M. V., Quagliariello, A., Reddel, S., Ianiro, G., Vicari, S., Gasbarrini, A., & Putignani, L. (2019) · Nutrients · doi:10.3390/nu11112812 · Cited by 214
Metadata
- Authors
- Marí-Bauset, S., Zazpe, I., Mari-Sanchis, A., Llopis-González, A., & Morales-Suárez-Varela, M.
- Affiliations
- Universitat de València (ES)
- Department of Nutrition and Food Sciences and Physiology, University of Navarra, Navarra, Spain
- Clinical Nutrition and Dietetics Unit, Navarra Hospital Complex, Navarra, Spain
- Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Valencia, Spain
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 2014-04-30
- Volume
- 29
- Issue
- 12
- Pages
- 1718-1727
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- OpenAlex
- W2011447176
- Semantic Scholar
- 1d7091aa87f7bd44dce0d3436ece1b2ebd569bc0
- Cited by
- 136
- References
- 67
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 10 · 2021: 17 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 18 · 2016: 9 · 2015: 12 · 2014: 8
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- gluten-free diet, casein-free diet, autism spectrum disorder, dietary intervention, food intolerance, food allergy, alternative treatment, quality of evidence
- MeSH terms
- Caseins, Child Development Disorders, Pervasive, Diet Therapy, Humans, Diet, Gluten-Free
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