Development and hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity
Open accessAbstract
Hemocompatibility is the goal for any biomaterial contained in extracorporeal life supporting medical devices. The hallmarks for hemocompatibility include nonthrombogenicity, platelet preservation, and maintained platelet function. Both in vitro and in vivo assays testing for compatibility of the blood/biomaterial interface have been used over the last several decades to ascertain if the biomaterial used in medical tubing and devices will require systemic anticoagulation for viability. Over the last 50 years systemic anticoagulation with heparin has been the gold standard in maintaining effective extracorporeal life supporting. However, the biomaterial that maintains effective ECLS without the use of any systemic anticoagulant has remained elusive. In this review, the in vivo 4-h rabbit thrombogenicity model genesis will be described with emphasis on biomaterials that may require no systemic anticoagulation for extracorporeal life supporting longevity. These novel biomaterials may improve extracorporeal circulation hemocompatibility by preserving near resting physiology of the major blood components, the platelets and monocytes. The rabbit extracorporeal circulation model provides a complete assessment of biomaterial interactions with the intrinsic coagulation players, the circulating platelet and monocytes. This total picture of blood/biomaterial interaction suggests that this rabbit thrombogenicity model could provide a standardization for biomaterial hemocompatibility testing.
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References 176 · Cited by 43
Research works printed but not linked: 5
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- Authors
- Major, T. C., Handa, H., Annich, G. M., & Bartlett, R. H.
- Affiliations
- Michigan Medicine (US)
- Corresponding author
- Major, Terry C
- Venue
- Journal of Biomaterials Applications
- Publisher
- SAGE Publications
- Published
- 2014-06-16
- Volume
- 29
- Issue
- 4
- Pages
- 479-501
- ISSN
- 0885-3282 (ISSN-L)
- 1530-8022
- PMC
- PMC4165720
- OpenAlex
- W2161148947
- Cited by
- 43
- References
- 176
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 8 · 2014: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Biomaterials Applications (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K25HL111213)
- National Institute of Biomedical Imaging and Bioengineering (R21EB016236)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD015434)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Biomedical Engineering › Mechanical Circulatory Support Devices
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- hemocompatibility, extracorporeal life support, thrombogenicity, anticoagulation, heparin, platelet storage, platelet function, monocytes, extracorporeal circulation, hemostasis
- MeSH terms
- Animals, Anticoagulants, Biocompatible Materials, Delayed-Action Preparations, Extracorporeal Circulation, Hemostasis, Materials Testing, Polymers, Rabbits, Thrombosis, Platelet Activation, Nitric Oxide Donors, Coated Materials, Biocompatible, Models, Animal
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