HSP70-2 (HSPA1B) is Associated with Noncognitive Symptoms in Late-Onset Alzheimer's Disease
Abstract
Neuropsychiatric manifestations are common in Alzheimer's disease (AD) and their phenotypic expression might be related to physiopathological and genetic causes. Multiple studies have implicated oxidative stress to the pathogenesis and possible etiology of AD. One of the mechanisms to protect cells from oxidative stress is the expression of heat-shock proteins (HSP). HSPA1B (alternatively known as HSP70-2) has been related to AD pathophysiology. In the present analysis, 77 AD patients were classified according to their cognitive status with the Neuropsychiatric Inventory and were genotyped for an insertion/deletion (A1/A2) polymorphism. The A2 allele conferred a significant increase of psychiatric morbidity in an allele-dose manner ( P < .05). This pattern can be attributed to all AD stages and the severity of the behavioral disturbances was higher for those patients carrying one or two A2 alleles. These results indicate a possible association between the A2 allele and an overexpression of noncognitive symptoms in AD. ( J Geriatr Psychiatry Neurol 2003: 16-146-150).
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Hspa1b (Hsp70-2) is associated with increased oxidative stress and initiation of Alzheimer's disease pathology.
“Most importantly there was downregulation of key protective heat shock protein (Hspa1b or Hsp70-2), associated with increased oxidative stress and initiation of AD pathology81.”
From Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk (2022) · cites this paper as [81]
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Chacko, A., Delbaz, A., Walkden, H., Basu, S., Armitage, C. W., Eindorf, T., Trim, L. K., Miller, E., West, N. P., St John, J. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-06749-9 · Cited by 65 · see citing works
- Authors
- Clarimón, J., Bertranpetit, J., Boada, M., Tàrraga, L., & Comas, D.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Fundació ACE. I.C. Neurociències Aplicades, Barcelona, Spain
- Venue
- Journal of Geriatric Psychiatry and Neurology
- Publisher
- SAGE Publications
- Published
- 2003-09
- Volume
- 16
- Issue
- 3
- Pages
- 146-150
- ISSN
- 0891-9887 (ISSN-L)
- 1552-5708
- OpenAlex
- W2094136860
- Cited by
- 44
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Geriatric Psychiatry and Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- HSP70-2, HSPA1B, late-onset Alzheimer's disease, neuropsychiatric symptoms, behavioral problems, insertion/deletion polymorphism, oxidative stress, heat shock proteins, genetic association, Neuropsychiatric Inventory
- MeSH terms
- Age Factors, Aged, Alzheimer Disease, Cognition, Female, Genotype, Humans, Male, Phenotype, Polymorphism, Genetic, Gene Deletion, Oxidative Stress, HSP70 Heat-Shock Proteins
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