IL-15 Is Elevated in Cerebrospinal Fluid of Patients With Alzheimer’s Disease and Frontotemporal Dementia
Abstract
Interleukin-15 is a novel proinflammatory cytokine. It is produced by activated blood monocytes, macrophages, and glial cells. The objective of our study was to assess the role of interleukin-15 as a marker of increased proinflammatory activity in patients with Alzheimer’s disease and frontotemporal dementia. We measured cerebrospinal fluid interleukin-15 levels in 17 patients with Alzheimer’s disease and 7 patients with frontotemporal dementia in comparison with 17 patients with amyotrophic lateral sclerosis and 15 patients with Parkinson’s disease. Patients with Alzheimer’s disease and frontotemporal dementia had significantly higher cerebrospinal fluid interleukin-15 levels compared with patients with noninflammatory neurological diseases ( P < .05 and P < .01, respectively). In Alzheimer’s disease, a significant positive correlation was noted between interleukin-15 levels and age of onset ( R = .48, P = .05). Our findings suggest that interleukin-15 may be implicated in the pathophysiology of Alzheimer’s disease and frontotemporal dementia.
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Earlier investigations that have measured CSF and blood levels of ICAM-1, VCAM-1, and IL-15 in AD have produced conflicting results.
“Earlier investigations that have measured CSF and blood levels of ICAM-1, VCAM-1, and IL-15 in AD have produced conflicting results.38–42”
From CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease (2018) · cites this paper as [42]
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References 31 · Cited by 65
- Authors
- Rentzos, M., Zoga, M., Paraskevas, G. P., Kapaki, E., Rombos, A., Nikolaou, C., Tsoutsou, A., & Vassilopoulos, D.
- Affiliations
- Eginition Hospital (GR)
- Corresponding author
- Rentzos, M.
- Venue
- Journal of Geriatric Psychiatry and Neurology
- Publisher
- SAGE Publications
- Published
- 2006-06
- Volume
- 19
- Issue
- 2
- Pages
- 114-117
- ISSN
- 0891-9887 (ISSN-L)
- 1552-5708
- OpenAlex
- W2084670312
- Cited by
- 65
- References
- 31
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 5 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Geriatric Psychiatry and Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- IL-15, cerebrospinal fluid biomarkers, Alzheimer's disease, frontotemporal dementia, neuroinflammation, inflammatory cytokines, amyotrophic lateral sclerosis, Parkinson's disease, age of onset
- MeSH terms
- Alzheimer Disease, Amyotrophic Lateral Sclerosis, Dementia, Female, Humans, Male, Middle Aged, Parkinson Disease, Interleukin-15
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