Achieving Probiotic Effects via Modulating Oral Microbial Ecology
Open accessAbstract
Unlike many pathogens are foreign invaders, oral “pathogens” such as Streptococcus mutans are part of the “normal” oral microbial flora. While they express certain pathogenic properties, the balance of synergistic and antagonistic interactions determines whether these çommensal pathogens cause damage or not. Recognition of these microbial ecology based pathogeneses argues for new strategies for disease treatment and prevention. Probiotics, potentially beneficial live bacteria or yeasts, have been used to combat dental caries. This includes the application of S. mutans types that cannot produce acids or other bacteria that interfere with the pathogenic effects of S. mutans. While these approaches show therapeutic effects against S. mutans experimentally, the conversion into commercial products remains a challenge, due to safety and shelf life issues. New high-tech approaches, such as quorum sensing interference of pathogenic bacteria or targeted antimicrobial therapies, offer novel ways to achieve probiotic effects against dental caries.
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Mitogenic activities of proliferation of B and T lymphocyte cells are considered important properties of immune modulation.
“Mitogenic activities of proliferation of B and T lymphocyte cells are considered important properties of immune modulation [34,64].”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [64]
The paper’s “Passive immunization” section discusses vaccination strategies against dental caries, but not mitogenic activity or B- and T-lymphocyte proliferation. Searches for those terms and immune modulation found no passage addressing the claim; page numbers were not available in our copy. (LLM, conf=0.76)
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References 30 · Cited by 52
Research works printed but not linked: 2
- Harish K Varghese T 2006 Probiotics in humans – evidence based review Calicut Med J 4 e3
- Marquis RE Burne RA Parsonsons DT Casiano-Colon AE 1993 Arginine deiminase and alkaline generation in plaque Cariology for the nineties Bowen WH Tabak LA Univ. of Rochester Press Rochester, N.Y. 309 317
- Authors
- He, X., Lux, R., Kuramitsu, H. K., Anderson, M. H., & Shi, W.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Advances in Dental Research
- Publisher
- SAGE Publications
- Published
- 2009-07-31
- Volume
- 21
- Issue
- 1
- Pages
- 53-56
- ISSN
- 0895-9374 (ISSN-L)
- 1544-0737
- PMC
- PMC2777612
- OpenAlex
- W2147235171
- Cited by
- 52
- References
- 30
- Citations by year
- 2025: 4 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 2 · 2012: 3
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in Dental Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01de020102-10)
- National Institute of General Medical Sciences (GM54666, R01GM054666)
- National Institute of Dental and Craniofacial Research (R01DE009821, R01-DE020102, DE 09821, R01DE003258, DE 03258)
- National Institute on Minority Health and Health Disparities (MD01831, R41MD001831, R42MD001831)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- probiotics, Streptococcus mutans, dental caries, oral microbiota, quorum sensing interference, targeted antimicrobial therapy
- MeSH terms
- Bacterial Adhesion, Dental Caries, Dental Plaque, Humans, Immunization, Passive, Streptococcus mutans, Ecosystem, Biofilms, Probiotics, Antimicrobial Cationic Peptides, Quorum Sensing, Microbial Interactions
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