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Cited by 84Poxvirus research and outbreaksHerpesvirus Infections and TreatmentsVirology and Viral Diseases

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Progress in the Discovery of Compounds Inhibiting Orthopoxviruses in Animal Models

Smee, Donald F·2008·Antiviral Chemistry and Chemotherapy
DOI 10.1177/095632020801900302
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Abstract

Surrogate animal models must be used for testing antiviral agents against variola (smallpox) virus infections. Once developed, these compounds can be stockpiled for use in the event of a bioterrorist incident involving either variola or monkeypox virus, or used to treat an occasional serious orthopoxvirus infection, such as disseminated vaccinia complication following expo-sure to the live virus vaccine. Recently, considerable progress has been made in the discovery of novel anti-viral agents found active against orthopoxviruses in vivo. This includes the development of new animal models or refinement of existing ones for compound efficacy testing. Current mouse models employ ectromelia, cowpox and vaccinia (WR and IHD strains) viruses with respiratory (lung) or tail lesion infections commonly studied. Rabbitpox and vaccinia (WR strain) viruses are available for rabbit infections. Monkeypox and variola viruses are used for infecting monkeys. This review describes these and other animal models, and covers compounds found active in vivo from 2003 to date. Cidofovir, known to be active against orthopox virus infections prior to 2003, has been studied extensively over recent years. New compounds showing promise are orally active inhibitors of orthopoxvirus infections that include ether lipid prodrugs of cidofovir and ( S)-HPMPA, ST-246, N-meth-anocarbathymidine ( N-MCT) and SRI 21950 (a 4'-thio derivative of iododeoxyuridine). Another compound with high activity but requiring parenteral administration is HPMPO-DAPy. Further development of these compounds is warranted.

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Crossref · 10.1177/095632020801900302

Cites

77 of 77 references verified0 citation errors · 0 not checkable

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Citations

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Show all 77 references

Research works printed but not linked: 7

  1. Fenner F, 1997, Viral Pathogenesis, 535
  2. Chowchuvech E, 1970, Invest Ophthalmol, 9, 716
  3. Huggins JW, 1998, Antivir Res, 37, A73
  4. Schriewer J, 2004, Meth Mol Biol, 269, 289
  5. Huggins JW, 2003, Antivir Res, 57, A78
  6. Huggins J, 2006, Antivir Res, 70, A36
  7. Neyts J, 2004, Antivir Res, 62, A71

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Metadata

Authors
Smee, D. F.
Affiliations
Utah State University (US)
Corresponding author
Smee, Donald F
ORCID
Smee, Donald F
Venue
Antiviral Chemistry and Chemotherapy
Publisher
SAGE Publications
Published
2008-06
Volume
19
Issue
3
Pages
115-124
ISSN
  • 0956-3202 (ISSN-L)
  • 2040-2066
DOI
10.1177/095632020801900302
OpenAlex
W2326918441
Cited by
84
References
77
Citations by year
2026: 4 · 2025: 3 · 2024: 9 · 2023: 14 · 2022: 16 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 1
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Antiviral chemistry & chemotherapy (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Utah State University
  • National Institutes of Health (n01ai15435-19-0-2)
  • National Institute of Allergy and Infectious Diseases (N01-AI-15435)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › Poxvirus research and outbreaks
  • Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
orthopoxvirus, antiviral agents, animal models, variola virus, monkeypox virus, vaccinia virus, ectromelia virus, cowpox virus, rabbitpox virus, cidofovir, ST-246, bioterrorism preparedness, smallpox
MeSH terms
Cidofovir, Adenine, Animals, Antiviral Agents, Benzamides, Cytosine, Disease Models, Animal, Humans, Phthalimides, Prodrugs, Orthopoxvirus, Isoindoles, Drug Discovery, Organophosphonates

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