The DOI matches its Crossref record.
Inhibition of HIV Infection by Caffeoylquinic Acid Derivatives
Abstract
The caffeoylquinic acids 3,4,5-tri-O-caffeoylquinic acid (1) and 4,5-di-O-caffeoylquinic acid (2), as well as caffeic acid (4) and synapoic acid (5) were isolated from the plant Securidaka longipedunculata (polygalaceae). 1 exhibited a greater selective inhibition of HIV replication than 2 which had an anti-HIV activity similar to that of 3,4,5-tri-O-galloylquinic acid (3), isolated from Guiera senegalensis (combretaceae); 4 and 5 were ineffective and the structurally related compound rosmarinic acid (6) had only slight anti-HIV activity. Studies of the actions of these compounds suggest that inhibition of the viral reverse transcriptase in vitro is non-specific and that they act by specific binding to gp120 which prevents its interaction with CD4 on T-lymphocytes and thus inactivates virus infectivity.
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Cited by
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McDougall, B., King, P. J., Wu, B. W., Hostomsky, Z., Reinecke, M. G., & Robinson, W. E. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.1.140 · Cited by 210
Metadata
- Authors
- Mahmood, N., Moore, P. S., De Tommasi, N., De Simone, F., Colman, S., Hay, A. J., & Pizza, C.
- Affiliations
- MRC Collaborative Centre, 1–3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK
- Università degli Studi di Napoli, Dipartimento di Chimice delle Sostanze Naturali, Via Domenico Montesano, 49, Napoli, Italy
- National Institute for Medical Research (GB)
- Venue
- Antiviral Chemistry and Chemotherapy
- Publisher
- SAGE Publications
- Published
- 1993-08
- Volume
- 4
- Issue
- 4
- Pages
- 235-240
- ISSN
- 0956-3202 (ISSN-L)
- 2040-2066
- OpenAlex
- W2286752414
- Cited by
- 119
- References
- 0
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Antiviral chemistry & chemotherapy (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- caffeoylquinic acids, HIV inhibition, caffeic acid, rosmarinic acid, Guiera senegalensis, reverse transcriptase inhibition, gp120 binding, CD4 receptor, plant-derived antiviral compounds, T cells
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