The DOI matches its Crossref record.
Comparative Effects of Several Chelating Agents on the Toxicity, Distribution and Excretion of Aluminium
Abstract
The relative efficacy of citric, malic, malonic, oxalic and succinic acids, and deferoxamine mesylate (DFOA) on the toxicity, distribution and excretion in mice exposed to aluminum were compared. Chelating agents were administered intraperitoneally at a dose equal to one-fourth of their respective LD50. To determine the effect of the various chelators on the toxicity of aluminum, various doses of aluminum nitrate (938-3188 mg/kg) were administered intraperitoneally, followed by one of the chelators. Survival was recorded at the end of 14 days. Malic and succinic acids were the most effective. Malic acid and DFOA were the most effective in increasing the urinary excretion of aluminum. Citric acid was the most effective in increasing the faecal excretion of aluminum. Malonic, oxalic and succinic acids had no overall beneficial effects. Citric acid would appear to be the most effective agent of those tested in the prevention of acute aluminium intoxication. However, before the use of these compounds in human aluminium intoxication is possible, further investigations including the effects of these chelators after chronic aluminium intoxication are required.
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Other chelating agents such as citric, malonic, oxalic, and succinic acids have been used experimentally to reduce aluminum load in rats and mice.
“Other chelating agents such as citric, malonic, oxalic, and succinic acids have been used experimentally to reduce aluminum load in rats and mice (Domingo et al., 1988).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Domingo et al., 1988
Malic acid is a potent chelator of Al used in treatment of Al intoxication.
“Malic acid is also a potent chelator of Al used in treatment of Al intoxication (Domingo et al., 1988).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Domingo et al., 1988
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Cited by
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Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“Other chelating agents such as citric, malonic, oxalic, and succinic acids have been used experimentally to reduce aluminum load in rats and mice (Domingo et al., 1988).”
Background
Metadata
- Authors
- Domingo, J. L., Gómez, M., Llobet, J. M., & Corbella, J.
- Affiliations
- Laboratory of Toxicology and Biochemistry, School of Medicine, C/San Llorenç 21,43201-Reus
- Universitat de Barcelona (ES)
- Venue
- Human Toxicology
- Publisher
- SAGE Publications
- Published
- 1988-05
- Volume
- 7
- Issue
- 3
- Pages
- 259-262
- ISSN
- 0144-5952 (ISSN-L)
- OpenAlex
- W2016719017
- Cited by
- 36
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2019: 2 · 2017: 1 · 2015: 1 · 2012: 1
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- aluminum toxicity, citric acid, malic acid, malonic acid, oxalic acid, succinic acid, deferoxamine mesylate, survival, mice
- MeSH terms
- Aluminum, Animals, Chelating Agents, Citrates, Malates, Male, Malonates, Oxalates, Succinates, Time Factors, Tissue Distribution, Citric Acid, Succinic Acid, Oxalic Acid, Mice
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