The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome
Abstract
Women with antiphospholipid syndrome (APS) may have diverse pregnancy outcomes. The objective of this study was to evaluate pregnancy outcome in women with APS according to their clinical phenotype, i.e. thrombotic and obstetric APS. Eighty-three pregnancies in 67 women with APS were included in the study, including 21 with recurrent miscarriage (Group 1), 21 with late fetal loss or early delivery due to placental dysfunction (Group 2) and 41 with thrombotic APS (Group 3). Group 3 had higher rates of preterm delivery (26.8% versus 4.7%, p = 0.05) than Group 1 and more small for gestational age (SGA) babies than Group 2 (39.5% versus 4.8%, p = 0.003). Group 2 had significantly longer gestations compared with their pretreatment pregnancies (38.4 [28.4-41.4] versus 24.0 [18-35] weeks, p < 0.0001) and 100% live birth rate after treatment with aspirin and low-molecular-weight heparin (LMWH). In conclusion, women with thrombotic APS (Group 3) have higher rates of pregnancy complications than those with obstetric APS (Groups 1 and 2). Treatment with aspirin and LMWH is associated with improved outcomes for women with previous late fetal loss or early delivery due to placental dysfunction (Group 2).
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“In observational studies, treatment with LDA and therapeutic dose heparin was associated with live births in 79% of pregnancies on average.52 61–64”
From EULAR recommendations for the management of antiphospholipid syndrome in adults (2019) · cites this paper as [62]
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MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203
Brown, M. A., Lindheimer, M. D., de Swiet, M., Assche, A. V., & Moutquin, J. (2001) · Hypertension in Pregnancy · doi:10.1081/prg-100104165 · Cited by 1,894
Levine, J. S., Branch, D. W., & Rauch, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra002974 · Cited by 1,524
Brown, M. A., Lindheimer, M. D., de SWIET, M., et al. (2001) · Hypertension in Pregnancy · doi:10.3109/10641950109152635 · Cited by 1,369
Rai, R., Cohen, H., Dave, M., & Regan, L. (1997) · BMJ · doi:10.1136/bmj.314.7076.253 · Cited by 1,113
Antiplatelet agents for preventing pre-eclampsia and its complications
Duley, L., Henderson-Smart, D. J., Meher, S., & King, J. F. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004659.pub2 · Cited by 1,016
Venous Thromboembolism, Thrombophilia, Antithrombotic Therapy, and Pregnancy
Bates, S. M., Greer, I. A., Pabinger, I., Sofaer, S., & Hirsh, J. (2008) · CHEST Journal · doi:10.1378/chest.08-0761 · Cited by 790
Cowchock, F. S., Reece, E. A., Balaban, D. J., Branch, D. W., & Plouffe, L. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91596-3 · Cited by 585
Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant
Empson, M. B., Lassere, M., Craig, J. C., & Scott, J. R. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002859.pub2 · Cited by 486
(1992) · PubMed · Cited by 434
Research works printed but not linked: 11
- Loizou S., 1988, Q J Med, 68, 525
- Branch DW, 1992, Obstet Gynecol, 80, 614
- Ruffatti A., 1997, Clin Exp Rheumatol, 15, 499
- Rosove MH, 1990, Obstet Gynecol, 75, 630
- Lima F., 1996, Clin Exp Rheumatol, 14, 131
- Gestation Network Centile Calculator
- Huong DL, 2001, J Rheumatol, 28, 2025
- Branch DW, 2003, Obstet Gynecol, 101, 1333
- Duley L., 2007, Cochrane Database Syst Rev, CD004659
- Sullivan A., 2001, Contemp Obstet Gynecol, 46, 100
- Empson M., 2005, Cochrane Database Syst Rev, CD002859
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EULAR recommendations for the management of antiphospholipid syndrome in adults
Tektonidou, M. G., Andreoli, L., Limper, M., Amoura, Z., Cervera, R., Costedoat-Chalumeau, N., Cuadrado, M. J., Dörner, T., Ferrer-Oliveras, R., Hambly, K., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215213 · Cited by 1,318
Self-citationRuiz‐Irastorza, G., Crowther, M. A., Branch, W. D., & Khamashta, M. A. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60709-x · Cited by 875
Self-citationSchreiber, K. I., Sciascia, S., de Groot, P. G., Devreese, K. M. J., Jacobsen, S., Ruiz‐Irastorza, G., Salmon, J. E., Shoenfeld, Y., Shovman, O., & Hunt, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.103 · Cited by 445
Self-citationManagement of the obstetric antiphospholipid syndrome
Derksen, R. H. W. M., Khamashta, M. A., & Branch, D. W. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20105 · Cited by 200
Self-citationSciascia, S., Hunt, B. J., Talavera-García, E., Lliso-Ribera, G., Khamashta, M. A., & Cuadrado, M. J. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.09.078 · Cited by 201
Self-citation
Metadata
- Authors
- Bramham, K., Hunt, B., Germain, S., Calatayud, I., Khamashta, M., Bewley, S., & Nelson-Piercy, C.
- Affiliations
- Guy's Hospital (GB)
- Department of Maternal Medicine, Women's services directorate and Lupus Unit, Guy's & St Thomas' NHS Foundation Trust, London, UK
- Department of Maternal Medicine, Women's services directorate and Lupus Unit, Guy's & St Thomas' NHS Foundation Trust, London, UK,
- Venue
- Lupus
- Publisher
- SAGE Publications
- Published
- 2009-11-06
- Volume
- 19
- Issue
- 1
- Pages
- 58-64
- ISSN
- 0961-2033 (ISSN-L)
- 1477-0962
- OpenAlex
- W2043383287
- Cited by
- 185
- References
- 40
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 15 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 17 · 2013: 13 · 2012: 15
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lupus (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (DRF-2009-02-18)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- antiphospholipid syndrome, pregnancy outcomes, clinical phenotype, thrombotic antiphospholipid syndrome, obstetric antiphospholipid syndrome, recurrent pregnancy loss, placental insufficiency, preterm birth, small for gestational age, aspirin, low molecular weight heparin
- MeSH terms
- Adult, Aspirin, Female, Heparin, Low-Molecular-Weight, Humans, Infant, Newborn, Infant, Small for Gestational Age, Obstetric Labor, Premature, Phenotype, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Retrospective Studies, Antiphospholipid Syndrome
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