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Cited by 102Mesenchymal stem cell researchAcute Ischemic Stroke ManagementStroke Rehabilitation and Recovery

Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke

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Wang, Fan, Tang, Hailiang, Zhu, Jianhong, Zhang, John H.·2018·Cell Transplantation
DOI 10.1177/0963689718795424PMC PMC6300770
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Abstract

Stroke is a major disease that leads to high mortality and morbidity. Given the ageing population and the potential risk factors, the prevalence of stroke and socioeconomic burden associated with stroke are expected to increase. During the past decade, both prophylactic and therapeutic strategies for stroke have made significant progress. However, current therapies still cannot adequately improve the outcomes of stroke and may not apply to all patients. One of the significant advances in modern medicine is cell-derived neurovascular regeneration and neuronal repair. Progress in stem cell biology has greatly contributed to ameliorating stroke-related brain injuries in preclinical studies and demonstrated clinical potential in stroke treatment. Mesenchymal stem cells (MSCs) have the differentiating potential of chondrocytes, adipocytes, and osteoblasts, and they have the ability to transdifferentiate into endothelial cells, glial cells, and neurons. Due to their great plasticity, MSCs have drawn much attention from the scientific community. This review will focus on MSCs, stem cells widely utilized in current medical research, and evaluate their effect and potential of improving outcomes in ischemic stroke.

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  • Intravenous administration of BM-MSCs leads to segregation of the neurotrophic factors BDNF, FGF-2, HGF, IGF-1, NAP-2 and VEGF, stimulating neuronal growth and post-stroke neovascularization.

    “Similarly, intravenous (i.v.) administration of BM-MSCs has led to segregation of the neurotrophic factors BDNF, FGF-2, HGF, IGF-1, NAP-2 and VEGF, stimulating neuronal growth and post-stroke neovascularization [17].”

    From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [17]

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Authors
Wang, F., Tang, H., Zhu, J., & Zhang, J. H.
Affiliations
  • Shanghai Medical College of Fudan University (CN)
  • Loma Linda University (US)
Corresponding author
  • Zhu, Jianhong
  • Zhang, John H.
ORCID
Venue
Cell Transplantation
Publisher
SAGE Publications
Published
2018-09-25
Volume
27
Issue
12
Pages
1825-1834
ISSN
  • 0963-6897 (ISSN-L)
  • 1555-3892
DOI
10.1177/0963689718795424
PMC
PMC6300770
OpenAlex
W2894454209
Cited by
102
References
102
Citations by year
2026: 2 · 2025: 7 · 2024: 11 · 2023: 31 · 2022: 17 · 2021: 19 · 2020: 11 · 2019: 4
FWCI
4.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Transplantation (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Keywords
mesenchymal stem cells, ischemic stroke, neurovascular regeneration, neural repair, stem cell plasticity, stroke treatment, brain injury
MeSH terms
Animals, Cell Differentiation, Clinical Trials as Topic, Humans, Neurons, Neovascularization, Physiologic, Stroke, Mesenchymal Stem Cell Transplantation, Neurogenesis, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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