Review: From therapy to experimental model: a hundred years of endotoxin administration to human subjects
Abstract
This article is a review of studies in which endotoxin has been administered to human subjects for experimental purposes. Data are presented in tabular form so the reader can better appreciate the objectives of individual studies. Although the original intention was to focus on the adverse events associated with these studies, unexpected serious adverse events rarely have been reported.
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The alterations in cytokines and cortisol levels observed in this study resemble those reported in other studies employing comparable amounts (0.4 ng/kg) of intravenously administered LPS.
“The alterations in cytokines and cortisol levels observed in this study resemble those reported in other studies employing comparable amounts (0.4 ng/kg) of intravenously administered LPS [36].”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [36]
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References 183 · Cited by 108
- Authors
- Bahador, M., & Cross, A. S.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Bahador, Marjan
- ORCID
- Cross, Alan S.
- Venue
- Journal of Endotoxin Research
- Publisher
- SAGE Publications
- Published
- 2007-10
- Volume
- 13
- Issue
- 5
- Pages
- 251-279
- ISSN
- 0968-0519 (ISSN-L)
- OpenAlex
- W2027163418
- Semantic Scholar
- 86997b1fecbd17e47cba7c72317483d0ee69ddda
- Cited by
- 108
- References
- 183
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 2 · 2019: 2 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 9 · 2014: 7 · 2013: 6 · 2012: 7
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endotoxin Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
- Keywords
- research participants, experimental model, adverse events, sepsis, lipopolysaccharide
- MeSH terms
- Anti-Inflammatory Agents, Non-Steroidal, Blood Coagulation, Endotoxins, Humans, Leukocytes, Cytokines, Endothelial Cells, Drug-Related Side Effects and Adverse Reactions
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