The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Differential expression of TGFβ isoforms in breast cancer highlights different roles during breast cancer progression
Open accessAbstract
While TGFβ plays a critical role in tumor formation and progression, the role and contribution of its three different isoforms remain unclear. In this study, we aimed at elucidating the prognostic value of the TGFβ isoforms and assessed their expression levels in breast cancer patients at different stages of the disease. We found higher levels of TGFβ1 and TGFβ3 in cancer patients compared to normal tissues, with no significant changes in TGFβ2 expression. Similarly, TGFβ1 and TGFβ3, but not TGFβ2, showed higher expression levels in advanced lymph node–positive and metastatic tumors, suggesting different roles for the different isoforms in tumor progression and the metastatic process, while in the least aggressive molecular subtype (luminal A), expression of the three TGFβ isoforms significantly correlated with expression of both TGFβ receptors, such correlation only occurred between TGFβ1 and TGFβ3 and the TGFβ type II receptor (TβRII) in the highly aggressive basal-like subtype. Interestingly, a distinct and somehow opposite pattern was observed in HER-2 tumors, only showing significant association pattern between TGFβ2 and the TGFβ type I receptor (TβRI). Finally, the three TGFβ isoforms showed distinct association patterns with patient outcome depending on the different molecular subtype, highlighting context-dependent, differential prognostic values.
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“However, TGF-β3 is clearly expressed by stromal CAFs and mesenchymal tumor cells41,70,247”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [70]
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Cites
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TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944
Teixeira, A. F., ten Dijke, P., & Zhu, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00605 · Cited by 216
“The expression TGF-β isoforms (TGF-β1-3) is coordinated in tissues according to physiopathological conditions (Stenvers et al., 2003; Cooley et al., 2014; Denney et al., 2015; Hachim et al., 2018).”
BackgroundFibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid
Machlin, J. H., Barishansky, S. J., Kelsh, J. M., Larmore, M. J., Johnson, B. W., Pritchard, M. T., Pavone, M. E., & Duncan, F. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094902 · Cited by 65
Zhou, C.-X., Wang, D., Li, J., Wang, Q., Wo, L., Zhang, X., Hu, Z., Wang, Z., Zhan, M., He, M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2117988119 · Cited by 65
TGF-β signaling pathway: Therapeutic targeting and potential for anti-cancer immunity
Ali, S., Rehman, M. U., Yatoo, A. M., Arafah, A. M., Khan, A., Rashid, S., Majid, S., Ali, A., & Ali, M. N. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175678 · Cited by 60
Self-citation
Metadata
- Authors
- Hachim, M. Y., Hachim, I. Y., Dai, M., Ali, S., & Lebrun, J.-J.
- Affiliations
- McGill University Health Centre (CA)
- Corresponding author
- Lebrun, Jean-Jacques
- Venue
- Tumor Biology
- Publisher
- SAGE Publications
- Published
- 2018-01
- Volume
- 40
- Issue
- 1
- Pages
- 101042831774825
- ISSN
- 1010-4283 (ISSN-L)
- 1423-0380
- OpenAlex
- W2783563529
- Cited by
- 35
- References
- 38
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 7 · 2020: 10 · 2019: 1 · 2018: 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Tumor Biology (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- breast cancer, TGF-β1, TGF-beta2, TGF-beta3, tumor progression, metastasis, lymph node metastasis, TGF-beta receptor, breast cancer molecular subtypes, luminal A, basal-like subtype, HER2-positive breast cancer, prognostic factors, patient outcomes
- MeSH terms
- Breast Neoplasms, Female, Humans, Immunohistochemistry, Middle Aged, RNA, Messenger, Receptors, Transforming Growth Factor beta, Disease Progression, Spheroids, Cellular, Gene Expression Profiling, Cell Line, Tumor, Transforming Growth Factor beta1, Transforming Growth Factor beta2, Transforming Growth Factor beta3
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