Association Between Short-term Ambient Air Pollution and Psoriasis: A Time-Stratified Case-Crossover Study
Abstract
This time-stratified case-crossover study evaluated the association between short-term exposure to ambient air pollution and psoriasis. A total of 107 462 psoriasis cases between 2002 and 2016 were retrieved from Taiwan's National Health Insurance Research Database. Conditional logistic regression was used to estimate the association between air pollutants (O 3 , CO, NO 2 , SO 2 , PM 2.5 , and PM 10 ) and psoriasis with each interquartile range (IQR) increase. Consistent associations for psoriasis for each IQR increase in NO 2 and CO exposure were noted at lag 0 both in single-pollutant and multiple-pollutant model. Exposure on lag 0 had the highest odds ratio (OR), decreasing consecutively from lag 1 to lag 3. Both NO 2 and CO had a stronger influence among men, older patients (>60 years old), and patients with chronic disease. Short-term NO 2 and CO exposure was associated with psoriasis. This link might provide insights into how air pollution, at least in part, affects the epidemiology and pathogenesis of psoriasis.
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A study from China showed a higher risk for people aged 40 years and above and being male.
“a study from China showed a higher risk for people aged 40 years and above and being male [68, 71].”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [68]
In studies analyzing multiple air pollutants, the short-term association between psoriasis and air pollution showed a strong relationship with gaseous pollutants such as NO2, SO2, and CO.
“it was observed that a short-term association between psoriasis and AP showed a strong relationship with gaseous pollutants such as NO2, SO2, and CO [66, 68, 69]”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [68]
A study in Taiwan showed a higher risk of psoriasis for men, and for older patients (aged >60 years) due to NO2 and CO.
“a study in Taiwan showed a higher risk of psoriasis for men, and for older patients (aged >60 years) due to NO2 and CO”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [68]
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Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence
Singh, N., Schikowski, T., & Krutmann, J. (2026) · American Journal of Clinical Dermatology · doi:10.1007/s40257-026-01006-5 · Cited by 4 · see citing works
“In contrast, a study in Taiwan showed a higher risk of psoriasis for men, and for older patients (aged >60 years) due to NO 2 and CO, and a study from China showed a higher risk for people aged 40 years and above and being male [68, 71].”
- Authors
- Chen, Y.-T., Li, Y.-L., Wu, C.-Y., Chen, L.-Y., & Chiou, H.-Y.
- Affiliations
- Taipei Medical University-Shuang Ho Hospital (TW)
- National Health Research Institutes (TW)
- Health Data Analytics and Statistics Center, Office of Data Science, Taipei Medical University, Taipei
- Corresponding author
- Chiou, Hung-Yi
- Venue
- Asia Pacific Journal of Public Health
- Publisher
- SAGE Publications
- Published
- 2025-03-29
- Volume
- 37
- Issue
- 4
- Pages
- 386-393
- ISSN
- 1010-5395 (ISSN-L)
- 1941-2479
- OpenAlex
- W4408963930
- Cited by
- 3
- References
- 0
- Citations by year
- 2026: 3
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Asia Pacific Journal of Public Health (publishedVersion)
- PubMed (publishedVersion)
- NHRI Institutional Repository (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- psoriasis, ambient air pollution, short-term exposure, nitrogen dioxide, carbon monoxide, ozone, particulate matter, lagged exposure, sex differences, chronic comorbidities
- MeSH terms
- Adult, Aged, Air Pollutants, Air Pollution, Environmental Exposure, Female, Humans, Male, Middle Aged, Psoriasis, Taiwan, Time Factors, Cross-Over Studies, Young Adult
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