The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Osteopontin
Open accessAbstract
Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. OPN is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell attachment/signaling. Expression of OPN in a variety of tissues indicates a multiplicity of functions that involve one or more of these conserved motifs. While the lack of a clear phenotype in OPN "knockout" mice has not established a definitive role for OPN in any tissue, recent studies have provided some novel and intriguing insights into the versatility of this enigmatic protein in diverse biological events, including developmental processes, wound healing, immunological responses, tumorigenesis, bone resorption, and calcification. The ability of OPN to stimulate cell activity through multiple receptors linked to several interactive signaling pathways can account for much of the functional diversity. In this review, we discuss the structural features of OPN I hat relate to its function in the formation, remodeling, and maintenance of bones and teeth.
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Cites
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Parfitt, A. M. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240550303 · Cited by 1,001
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.
Burgess, T. L., Qian, Y.-X., Kaufman, S., Ring, B. D., Van, G., Capparelli, C., Kelley, M., Hsu, H., Boyle, W. J., Dunstan, C. R., et al. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.3.527 · Cited by 689
Ross, F. P., Chappel, J., Alvarez, J. I., Sander, D., Butler, W. T., Farach-Carson, M. C., Mintz, K. A., Robey, P. G., Teitelbaum, S. L., & Cheresh, D. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98430-9 · Cited by 537
β1 integrins and osteoclast function: Involvement in collagen recognition and bone resorption
Helfrich, M. H., Nesbitt, S. A., Lakkakorpi, P. T., Barnes, M. J., Bodary, S. C., Shankar, G., Mason, W. T., Mendrick, D. L., Väänänen, H. K., & Horton, M. A. (1996) · Bone · doi:10.1016/s8756-3282(96)00223-2 · Cited by 139
Cited by
Phosphorylated Proteins and Control over Apatite Nucleation, Crystal Growth, and Inhibition
George, A., & Veis, A. (2008) · Chemical Reviews · doi:10.1021/cr0782729 · Cited by 745
Structure of periodontal tissues in health and disease*
Nanci, A., & Bosshardt, D. D. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2005.00141.x · Cited by 677
Osteopontin: role in immune regulation and stress responses
Wang, K. X., & Denhardt, D. T. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.08.001 · Cited by 669
Extracellular matrix in the trabecular meshwork
Acott, T. S., & Kelley, M. J. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.01.013 · Cited by 503
Qin, C., Baba, O., & Butler, W. T. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500302 · Cited by 439
Metadata
- Authors
- Sodek, J., Ganss, B., & McKee, M. D.
- Venue
- Critical Reviews in Oral Biology & Medicine
- Publisher
- SAGE Publications
- Published
- 2000-07
- Volume
- 11
- Issue
- 3
- Pages
- 279-303
- ISSN
- 1045-4411 (ISSN-L)
- 1544-1113
- OpenAlex
- W4211142228
- Cited by
- 993
- References
- 5
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
