Neuropathological and Genetic Findings in Autism: The Significance of a Putative Minicolumnopathy
Abstract
Autism is a condition manifested as abnormalities of relatedness, communication, range of interests, and repetitive behaviors. Despite alarming prevalence estimates and exhortations to research, little is known regarding its pathophysiology. Recent reports of a putative minicolumnopathy explain changes in brain size, gray/white matter ratios, and interareal connectivity. This article summarizes possible links between minicolumns and other topics—cortical modularity, age of onset, gliosis, and genetics—relevant to the pathophysiology of autism.
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ASD subjects have a significant increase in neuropil in the frontopolar region and anterior cingulate gyrus, but not in primary visual, motor, somatosensory, or dorsolateral prefrontal association cortices.
“Subjects with ASD also have a significant increase in neuropil, comprising the dendrites, non-myelinated axons, synapses, vasculature and glial cell processes present in between cell bodies, in the frontopolar region and the anterior cingulate gyrus, but not in the primary visual, motor, and somatosensory and dorsolateral prefrontal association cortices [54].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [54]
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References 79 · Cited by 109
- Authors
- Casanova, M. F.
- Affiliations
- University of Louisville (US)
- Corresponding author
- Casanova, Manuel F.
- ORCID
- Casanova, Manuel F.
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2006-10
- Volume
- 12
- Issue
- 5
- Pages
- 435-441
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2127154740
- Cited by
- 109
- References
- 79
- Citations by year
- 2026: 4 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 14 · 2012: 6
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH062654, R01MH061606, MH 61606, MH62654, R01MH069991, MH 69991)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, minicolumns, brain size, gray-white matter ratio, gliosis, age of onset, autism genetics, neuropathology, pathophysiology
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Autistic Disorder, Brain, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Age of Onset
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